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- W2000707342 abstract "Langerhans cell histiocytosis (LCH), or histiocytosis X, is now generally considered to be a non-malignant condition. A flow cytometric (FCM) study of a single case has, however, been published which claimed to provide evidence to contradict this. The presence of DNA-ploidy as detected using this technique is a feature of malignant and pre-malignant disease. In this reported single case, DNA-ploidy was present but the clinical features of this patient were atypical for LCH. We have performed a FCM study of the DNA of nine biopsies of LCH lesions from six patients with well-established disease. In addition, in one of these, fresh tissue studies including the use of an anti-CD I monoclonal antibody to specifically label the LCH cells were performed. In all cases the DNA content of the cells was entirely normal. We therefore found no evidence that LCH is a neoplastic disorder." @default.
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- W2000707342 date "1989-04-01" @default.
- W2000707342 modified "2023-09-30" @default.
- W2000707342 title "A flow cytometric study of Langerhans cell histiocytosis" @default.
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- W2000707342 doi "https://doi.org/10.1111/j.1365-2133.1989.tb01321.x" @default.
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