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- W2000707979 abstract "The effect of chewable isosorbide dinitrate on submaximal bicycle exercise capacity was evaluated in a double-blind randomized study involving 13 patients with chronic heart failure. All patients had impaired maximal exercise capacity ( V ˙ o2 max = 12.0 ± 2.6 ml/kg/min) due to fatigue and dyspnea but not angina. The administration of isosorbide dinitrate lowered the resting mean blood pressure (82 ± 9 mm Hg to 78 ± 10 mm Hg, (p < 0.03)) and the resulting pulmonary wedge pressure (26 ± 5 mm Hg to 12 ± 6 mm Hg, (p < 0.01)). Isosorbide dinitrate acutely improved exercise duration during upright bicycle exercise at a workload fixed at 50 percent of the maximal workload (placebo: 21.8 ± 14.1 min vs isosorbide dinitrate: 31.4 ± 13.6 min, (p < 0.003)) due to reduced exertional dyspnea. Administration of chewable isosorbide dinitrate acutely improved submaximal exercise tolerance in patients with chronic heart failure. The effect of chewable isosorbide dinitrate on submaximal bicycle exercise capacity was evaluated in a double-blind randomized study involving 13 patients with chronic heart failure. All patients had impaired maximal exercise capacity ( V ˙ o2 max = 12.0 ± 2.6 ml/kg/min) due to fatigue and dyspnea but not angina. The administration of isosorbide dinitrate lowered the resting mean blood pressure (82 ± 9 mm Hg to 78 ± 10 mm Hg, (p < 0.03)) and the resulting pulmonary wedge pressure (26 ± 5 mm Hg to 12 ± 6 mm Hg, (p < 0.01)). Isosorbide dinitrate acutely improved exercise duration during upright bicycle exercise at a workload fixed at 50 percent of the maximal workload (placebo: 21.8 ± 14.1 min vs isosorbide dinitrate: 31.4 ± 13.6 min, (p < 0.003)) due to reduced exertional dyspnea. Administration of chewable isosorbide dinitrate acutely improved submaximal exercise tolerance in patients with chronic heart failure." @default.
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- W2000707979 date "1982-12-01" @default.
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- W2000707979 title "Effect of Isosorbide Dinitrate on Submaximal Exercise Capacity of Patients with Chronic Left Ventricular Failure" @default.
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- W2000707979 doi "https://doi.org/10.1378/chest.82.6.701" @default.
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