Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000710891> ?p ?o ?g. }
- W2000710891 endingPage "120" @default.
- W2000710891 startingPage "111" @default.
- W2000710891 abstract "Inhibition of ribonucleotide reductase (RR) has gained attention as a potential strategy for HIV-1 therapy through the success of hydroxyurea (HU) to potentiate the activity of the nucleoside reverse transcriptase inhibitor (NRTI) didanosine (ddI) in clinical trials. However, the use of HU has been limited by its development of hematopoietic toxicity. In this study, the novel RR inhibitors didox (DX; 3,4-dihydroxybenzohydroxamic acid), and trimidox (TX; 3,4,5-trihydroxybenzamidoxime) were evaluated along with HU for anti-retroviral efficacy in LPBM5-induced retro-viral disease (MAIDS) both as monotherapeutic regimens and in combination with the guanine containing NRTI abacavir (ABC). Anti-retroviral drug efficacy was determined by measuring inhibition of splenomegaly, hypergammaglobulinemia, and splenic levels of proviral DNA. In this study, all RRIs tested showed the ability to improve the efficacy of ABC in the MAIDS model by reducing splenomegaly, hypergammaglobulinemia, and splenic proviral DNA levels." @default.
- W2000710891 created "2016-06-24" @default.
- W2000710891 creator A5011033762 @default.
- W2000710891 creator A5043335314 @default.
- W2000710891 creator A5044203371 @default.
- W2000710891 creator A5068495574 @default.
- W2000710891 creator A5071851326 @default.
- W2000710891 creator A5083580874 @default.
- W2000710891 creator A5088153898 @default.
- W2000710891 creator A5090348719 @default.
- W2000710891 date "2004-06-01" @default.
- W2000710891 modified "2023-09-25" @default.
- W2000710891 title "In vivo examination of hydroxyurea and the novel ribonucleotide reductase inhibitors trimidox and didox in combination with the reverse transcriptase inhibitor abacavir: suppression of retrovirus-induced immunodeficiency disease" @default.
- W2000710891 cites W102098040 @default.
- W2000710891 cites W141462965 @default.
- W2000710891 cites W1498992791 @default.
- W2000710891 cites W1569117171 @default.
- W2000710891 cites W1594848307 @default.
- W2000710891 cites W1596026758 @default.
- W2000710891 cites W1648486104 @default.
- W2000710891 cites W1897890183 @default.
- W2000710891 cites W1952037122 @default.
- W2000710891 cites W1968716613 @default.
- W2000710891 cites W1977506425 @default.
- W2000710891 cites W1982410689 @default.
- W2000710891 cites W1987145430 @default.
- W2000710891 cites W1988528612 @default.
- W2000710891 cites W1991584531 @default.
- W2000710891 cites W1995630317 @default.
- W2000710891 cites W2005910303 @default.
- W2000710891 cites W2019578579 @default.
- W2000710891 cites W2030055135 @default.
- W2000710891 cites W2030405093 @default.
- W2000710891 cites W2039020080 @default.
- W2000710891 cites W2039510124 @default.
- W2000710891 cites W2041372706 @default.
- W2000710891 cites W2058563502 @default.
- W2000710891 cites W2059289017 @default.
- W2000710891 cites W2064720997 @default.
- W2000710891 cites W2067430655 @default.
- W2000710891 cites W2078270239 @default.
- W2000710891 cites W2079891844 @default.
- W2000710891 cites W2084777423 @default.
- W2000710891 cites W2092778568 @default.
- W2000710891 cites W2095401749 @default.
- W2000710891 cites W2154533921 @default.
- W2000710891 cites W2163782297 @default.
- W2000710891 cites W2164273972 @default.
- W2000710891 cites W2167177203 @default.
- W2000710891 cites W2168772220 @default.
- W2000710891 cites W2174167667 @default.
- W2000710891 cites W2178778111 @default.
- W2000710891 cites W220680799 @default.
- W2000710891 cites W2316911370 @default.
- W2000710891 cites W2332258345 @default.
- W2000710891 cites W2405719659 @default.
- W2000710891 cites W2408854803 @default.
- W2000710891 cites W2413229695 @default.
- W2000710891 cites W2413847750 @default.
- W2000710891 cites W2415213076 @default.
- W2000710891 cites W2434886430 @default.
- W2000710891 cites W49920453 @default.
- W2000710891 doi "https://doi.org/10.1016/j.antiviral.2003.11.007" @default.
- W2000710891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15130534" @default.
- W2000710891 hasPublicationYear "2004" @default.
- W2000710891 type Work @default.
- W2000710891 sameAs 2000710891 @default.
- W2000710891 citedByCount "14" @default.
- W2000710891 countsByYear W20007108912012 @default.
- W2000710891 countsByYear W20007108912013 @default.
- W2000710891 countsByYear W20007108912017 @default.
- W2000710891 crossrefType "journal-article" @default.
- W2000710891 hasAuthorship W2000710891A5011033762 @default.
- W2000710891 hasAuthorship W2000710891A5043335314 @default.
- W2000710891 hasAuthorship W2000710891A5044203371 @default.
- W2000710891 hasAuthorship W2000710891A5068495574 @default.
- W2000710891 hasAuthorship W2000710891A5071851326 @default.
- W2000710891 hasAuthorship W2000710891A5083580874 @default.
- W2000710891 hasAuthorship W2000710891A5088153898 @default.
- W2000710891 hasAuthorship W2000710891A5090348719 @default.
- W2000710891 hasConcept C104292427 @default.
- W2000710891 hasConcept C104317684 @default.
- W2000710891 hasConcept C142462285 @default.
- W2000710891 hasConcept C156719811 @default.
- W2000710891 hasConcept C159047783 @default.
- W2000710891 hasConcept C2522874641 @default.
- W2000710891 hasConcept C2776452011 @default.
- W2000710891 hasConcept C2776694085 @default.
- W2000710891 hasConcept C2777351918 @default.
- W2000710891 hasConcept C2777447569 @default.
- W2000710891 hasConcept C2777869810 @default.
- W2000710891 hasConcept C2779316324 @default.
- W2000710891 hasConcept C2779465607 @default.
- W2000710891 hasConcept C2780216070 @default.
- W2000710891 hasConcept C2780593183 @default.
- W2000710891 hasConcept C2780727368 @default.
- W2000710891 hasConcept C2780866839 @default.
- W2000710891 hasConcept C2909970146 @default.