FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000711487> ?p ?o ?g. }

• W2000711487 endingPage "165" @default.
• W2000711487 startingPage "157" @default.
• W2000711487 abstract "We constructed mutant strains of Francisella tularensis biotype novicida by insertional mutagenesis with a kanamycin resistance (KmR) cassette. One mutant, KEM7, was defective for survival in macrophages in comparison with the wild-type (WT) strain and a random insertion strain, KEM21. While all three strains exhibited intracellular growth, the number of viable KEM7 present after 24–48 h of infection was approximately 10 times less than that of WT or KEM21. This observation was apparently due to a reduced number of viable KEM7 associated with the macrophages one hour after phagocytosis. KEM7 was approximately 3 times more susceptible than WT or KEM21 to killing by the products of the xanthine-xanthine oxidase reaction or by hydrogen peroxide. KEM7 was also found to be susceptible to killing by serum, whereas WT and KEM21 were resistant. Upon intravenous inoculation of C57BL/6 mice, the number of KEM7 in the livers and spleens 48 h post-infection was found to be 1000- to 10 000-times less than that of either KEM21 or WT. DNA sequence analysis at the KmR insertion site suggested that the F. tularensis homologue of minD had been interrupted. Western immunoblot analysis confirmed the presence of a MinD homologue in F. tularensis WT and KEM21, and demonstrated its absence in KEM7." @default.
• W2000711487 created "2016-06-24" @default.
• W2000711487 creator A5013264802 @default.
• W2000711487 creator A5033697683 @default.
• W2000711487 creator A5079086838 @default.
• W2000711487 creator A5087731284 @default.
• W2000711487 date "1994-12-01" @default.
• W2000711487 modified "2023-10-10" @default.
• W2000711487 title "Isolation of a Francisella tularensis mutant that is sensitive to serum and oxidative killing and is avirulent in mice: Correlation with the loss of MinD homologue expression" @default.
• W2000711487 cites W1421979160 @default.
• W2000711487 cites W1549355483 @default.
• W2000711487 cites W1594786514 @default.
• W2000711487 cites W1639307940 @default.
• W2000711487 cites W1644336418 @default.
• W2000711487 cites W1750275338 @default.
• W2000711487 cites W1917866540 @default.
• W2000711487 cites W1919469224 @default.
• W2000711487 cites W1941514458 @default.
• W2000711487 cites W1980119809 @default.
• W2000711487 cites W1980929124 @default.
• W2000711487 cites W2038487119 @default.
• W2000711487 cites W2043259359 @default.
• W2000711487 cites W2047560791 @default.
• W2000711487 cites W2091220292 @default.
• W2000711487 cites W2100837269 @default.
• W2000711487 cites W2105736821 @default.
• W2000711487 cites W2129461606 @default.
• W2000711487 cites W2143629111 @default.
• W2000711487 cites W2148189914 @default.
• W2000711487 cites W2161524167 @default.
• W2000711487 cites W2162247704 @default.
• W2000711487 cites W2266463247 @default.
• W2000711487 doi "https://doi.org/10.1111/j.1574-6968.1994.tb07278.x" @default.
• W2000711487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7813885" @default.
• W2000711487 hasPublicationYear "1994" @default.
• W2000711487 type Work @default.
• W2000711487 sameAs 2000711487 @default.
• W2000711487 citedByCount "34" @default.
• W2000711487 countsByYear W20007114872012 @default.
• W2000711487 countsByYear W20007114872013 @default.
• W2000711487 countsByYear W20007114872017 @default.
• W2000711487 crossrefType "journal-article" @default.
• W2000711487 hasAuthorship W2000711487A5013264802 @default.
• W2000711487 hasAuthorship W2000711487A5033697683 @default.
• W2000711487 hasAuthorship W2000711487A5079086838 @default.
• W2000711487 hasAuthorship W2000711487A5087731284 @default.
• W2000711487 hasBestOaLocation W20007114871 @default.
• W2000711487 hasConcept C104317684 @default.
• W2000711487 hasConcept C107635520 @default.
• W2000711487 hasConcept C143065580 @default.
• W2000711487 hasConcept C153911025 @default.
• W2000711487 hasConcept C159047783 @default.
• W2000711487 hasConcept C160448771 @default.
• W2000711487 hasConcept C16318435 @default.
• W2000711487 hasConcept C207583985 @default.
• W2000711487 hasConcept C2775983634 @default.
• W2000711487 hasConcept C2780467176 @default.
• W2000711487 hasConcept C2780796267 @default.
• W2000711487 hasConcept C2780920689 @default.
• W2000711487 hasConcept C501593827 @default.
• W2000711487 hasConcept C523546767 @default.
• W2000711487 hasConcept C54355233 @default.
• W2000711487 hasConcept C55493867 @default.
• W2000711487 hasConcept C60987743 @default.
• W2000711487 hasConcept C86803240 @default.
• W2000711487 hasConcept C89423630 @default.
• W2000711487 hasConceptScore W2000711487C104317684 @default.
• W2000711487 hasConceptScore W2000711487C107635520 @default.
• W2000711487 hasConceptScore W2000711487C143065580 @default.
• W2000711487 hasConceptScore W2000711487C153911025 @default.
• W2000711487 hasConceptScore W2000711487C159047783 @default.
• W2000711487 hasConceptScore W2000711487C160448771 @default.
• W2000711487 hasConceptScore W2000711487C16318435 @default.
• W2000711487 hasConceptScore W2000711487C207583985 @default.
• W2000711487 hasConceptScore W2000711487C2775983634 @default.
• W2000711487 hasConceptScore W2000711487C2780467176 @default.
• W2000711487 hasConceptScore W2000711487C2780796267 @default.
• W2000711487 hasConceptScore W2000711487C2780920689 @default.
• W2000711487 hasConceptScore W2000711487C501593827 @default.
• W2000711487 hasConceptScore W2000711487C523546767 @default.
• W2000711487 hasConceptScore W2000711487C54355233 @default.
• W2000711487 hasConceptScore W2000711487C55493867 @default.
• W2000711487 hasConceptScore W2000711487C60987743 @default.
• W2000711487 hasConceptScore W2000711487C86803240 @default.
• W2000711487 hasConceptScore W2000711487C89423630 @default.
• W2000711487 hasIssue "2" @default.
• W2000711487 hasLocation W20007114871 @default.
• W2000711487 hasLocation W20007114872 @default.
• W2000711487 hasOpenAccess W2000711487 @default.
• W2000711487 hasPrimaryLocation W20007114871 @default.
• W2000711487 hasRelatedWork W1979846117 @default.
• W2000711487 hasRelatedWork W2070463119 @default.
• W2000711487 hasRelatedWork W2153467600 @default.
• W2000711487 hasRelatedWork W2154913479 @default.
• W2000711487 hasRelatedWork W2169497969 @default.
• W2000711487 hasRelatedWork W2731056872 @default.
• W2000711487 hasRelatedWork W3088442014 @default.
• W2000711487 hasRelatedWork W3127778167 @default.

• next