Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000711529> ?p ?o ?g. }
- W2000711529 endingPage "4028" @default.
- W2000711529 startingPage "4028" @default.
- W2000711529 abstract "Gap junctions are intercellular channels that have been implicated in the pathogenesis of neuronal death after central nervous system injury. This study determines the expression pattern of gap junction protein connexin43 in the human retina and optic nerve.An affinity-isolated polyclonal antibody to the C-terminal segment of the cytoplasmic domain of human connexin43 was used to determine connexin43 localization. Postmortem human eyes were examined by immunohistochemical staining of frozen sections using antibodies to connexin43. Antibody binding was detected using confocal microscopy and fluorochrome-conjugated secondary antibodies. Double-label immunohistochemistry identified the cell types expressing connexin43.Connexin43 immunoreactivity was detected in the human retina on glial fibrillary acidic protein (GFAP)-positive astrocytes in the retinal ganglion cell layer and, to a lesser extent, on the processes of glutamine synthetase-labeled Müller cells. The retinal and choroidal circulations showed strong connexin43 immunolabeling. Dense connexin43 immunoreactivity was present between adjacent cells of the retinal pigment epithelium, and there was diffuse connexin43 immunoreactivity on GFAP-positive astrocytes in the optic nerve.In the human retina and optic nerve, connexin43 is present on glia, blood vessels, and epithelial cells. An understanding of the distribution of connexin43 in the normal retina and optic nerve may be used to evaluate changes associated with retinal and optic nerve disease." @default.
- W2000711529 created "2016-06-24" @default.
- W2000711529 creator A5018646368 @default.
- W2000711529 creator A5021252455 @default.
- W2000711529 creator A5045328177 @default.
- W2000711529 creator A5046539019 @default.
- W2000711529 creator A5050607445 @default.
- W2000711529 creator A5057620606 @default.
- W2000711529 creator A5078960009 @default.
- W2000711529 date "2010-08-01" @default.
- W2000711529 modified "2023-10-06" @default.
- W2000711529 title "Immunolocalization of Gap Junction Protein Connexin43 (GJA1) in the Human Retina and Optic Nerve" @default.
- W2000711529 cites W1593655973 @default.
- W2000711529 cites W1600901846 @default.
- W2000711529 cites W1648606954 @default.
- W2000711529 cites W1963909386 @default.
- W2000711529 cites W1975565709 @default.
- W2000711529 cites W1975742453 @default.
- W2000711529 cites W1984984255 @default.
- W2000711529 cites W1989102363 @default.
- W2000711529 cites W1989488177 @default.
- W2000711529 cites W1991312277 @default.
- W2000711529 cites W1991381764 @default.
- W2000711529 cites W1991914992 @default.
- W2000711529 cites W2000696964 @default.
- W2000711529 cites W2003300324 @default.
- W2000711529 cites W2007196696 @default.
- W2000711529 cites W2008831180 @default.
- W2000711529 cites W2015305787 @default.
- W2000711529 cites W2020194063 @default.
- W2000711529 cites W2022602979 @default.
- W2000711529 cites W2023548304 @default.
- W2000711529 cites W2024271418 @default.
- W2000711529 cites W2029937137 @default.
- W2000711529 cites W2032861334 @default.
- W2000711529 cites W2034771536 @default.
- W2000711529 cites W2036777729 @default.
- W2000711529 cites W2040710878 @default.
- W2000711529 cites W2041424646 @default.
- W2000711529 cites W2044407570 @default.
- W2000711529 cites W2052244093 @default.
- W2000711529 cites W2057053269 @default.
- W2000711529 cites W2057226590 @default.
- W2000711529 cites W2060539596 @default.
- W2000711529 cites W2061671071 @default.
- W2000711529 cites W2064197300 @default.
- W2000711529 cites W2069035576 @default.
- W2000711529 cites W2077845955 @default.
- W2000711529 cites W2082818638 @default.
- W2000711529 cites W2087995547 @default.
- W2000711529 cites W2092046923 @default.
- W2000711529 cites W2092474526 @default.
- W2000711529 cites W2095983744 @default.
- W2000711529 cites W2105465653 @default.
- W2000711529 cites W2115218292 @default.
- W2000711529 cites W2116973979 @default.
- W2000711529 cites W2122377300 @default.
- W2000711529 cites W2124600404 @default.
- W2000711529 cites W2125297320 @default.
- W2000711529 cites W2128738543 @default.
- W2000711529 cites W2137065941 @default.
- W2000711529 cites W2153469644 @default.
- W2000711529 cites W2168505250 @default.
- W2000711529 cites W2168631647 @default.
- W2000711529 cites W2204735243 @default.
- W2000711529 cites W2283713899 @default.
- W2000711529 cites W2604161218 @default.
- W2000711529 cites W3025227316 @default.
- W2000711529 cites W48347162 @default.
- W2000711529 doi "https://doi.org/10.1167/iovs.09-4847" @default.
- W2000711529 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20375327" @default.
- W2000711529 hasPublicationYear "2010" @default.
- W2000711529 type Work @default.
- W2000711529 sameAs 2000711529 @default.
- W2000711529 citedByCount "59" @default.
- W2000711529 countsByYear W20007115292012 @default.
- W2000711529 countsByYear W20007115292013 @default.
- W2000711529 countsByYear W20007115292014 @default.
- W2000711529 countsByYear W20007115292015 @default.
- W2000711529 countsByYear W20007115292016 @default.
- W2000711529 countsByYear W20007115292017 @default.
- W2000711529 countsByYear W20007115292018 @default.
- W2000711529 countsByYear W20007115292019 @default.
- W2000711529 countsByYear W20007115292020 @default.
- W2000711529 countsByYear W20007115292021 @default.
- W2000711529 countsByYear W20007115292022 @default.
- W2000711529 countsByYear W20007115292023 @default.
- W2000711529 crossrefType "journal-article" @default.
- W2000711529 hasAuthorship W2000711529A5018646368 @default.
- W2000711529 hasAuthorship W2000711529A5021252455 @default.
- W2000711529 hasAuthorship W2000711529A5045328177 @default.
- W2000711529 hasAuthorship W2000711529A5046539019 @default.
- W2000711529 hasAuthorship W2000711529A5050607445 @default.
- W2000711529 hasAuthorship W2000711529A5057620606 @default.
- W2000711529 hasAuthorship W2000711529A5078960009 @default.
- W2000711529 hasConcept C105702510 @default.
- W2000711529 hasConcept C142724271 @default.
- W2000711529 hasConcept C158157758 @default.