Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000712914> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2000712914 endingPage "22" @default.
- W2000712914 startingPage "17" @default.
- W2000712914 abstract "Nardostachys chinensis (N. chinensis) has been used in traditional medicine as a sedative and analgesic. It has been reported that N. chinensis extract has an antioxidant activity. However, the mechanism has not been elucidated. In this study, we showed that FOXO3a was activated by N. chinensis extract. FOXO3a is a transcriptional factor that involved in cell cycle arrest, DNA repair, apoptosis, and detoxification of reactive oxygen spices (ROS). Protein level of FOXO3a was increased by N. chinensis extract whereas phospho-FOXO3a (Thr 32) was not changed. Promoter activities of target genes of FOXO3a such as MnSOD, p27, and GADD45 were increased by N. chinensis extract. Among target genes, protein level of MnSOD was increased by N. chinensis extract, and this leads to removal of ROS level in human embryonic fibroblast (HEF) cells. These results suggested that N. chinensis extract has an antioxidant activity by upregulation of MnSOD through FOXO3a activation." @default.
- W2000712914 created "2016-06-24" @default.
- W2000712914 creator A5008978834 @default.
- W2000712914 creator A5017832724 @default.
- W2000712914 creator A5031357902 @default.
- W2000712914 creator A5032155136 @default.
- W2000712914 creator A5035459706 @default.
- W2000712914 creator A5053320499 @default.
- W2000712914 creator A5084226421 @default.
- W2000712914 date "2014-03-31" @default.
- W2000712914 modified "2023-10-16" @default.
- W2000712914 title "Mechanism for Antioxidant Activity of Nardostachys chinensis root Extract" @default.
- W2000712914 cites W1966828006 @default.
- W2000712914 cites W1973622869 @default.
- W2000712914 cites W1975163857 @default.
- W2000712914 cites W1977178308 @default.
- W2000712914 cites W1979857179 @default.
- W2000712914 cites W1981680273 @default.
- W2000712914 cites W2006851069 @default.
- W2000712914 cites W2006984764 @default.
- W2000712914 cites W2020777578 @default.
- W2000712914 cites W2044068920 @default.
- W2000712914 cites W2046623154 @default.
- W2000712914 cites W2048553024 @default.
- W2000712914 cites W2051124056 @default.
- W2000712914 cites W2082249759 @default.
- W2000712914 cites W2084299658 @default.
- W2000712914 cites W2093418569 @default.
- W2000712914 cites W2099364141 @default.
- W2000712914 cites W2116787167 @default.
- W2000712914 cites W2134199670 @default.
- W2000712914 cites W2137035181 @default.
- W2000712914 cites W2139856782 @default.
- W2000712914 cites W2155448474 @default.
- W2000712914 cites W2157633567 @default.
- W2000712914 cites W2162434225 @default.
- W2000712914 cites W2165201727 @default.
- W2000712914 cites W2166353463 @default.
- W2000712914 doi "https://doi.org/10.3839/jabc.2014.003" @default.
- W2000712914 hasPublicationYear "2014" @default.
- W2000712914 type Work @default.
- W2000712914 sameAs 2000712914 @default.
- W2000712914 citedByCount "2" @default.
- W2000712914 countsByYear W20007129142019 @default.
- W2000712914 countsByYear W20007129142021 @default.
- W2000712914 crossrefType "journal-article" @default.
- W2000712914 hasAuthorship W2000712914A5008978834 @default.
- W2000712914 hasAuthorship W2000712914A5017832724 @default.
- W2000712914 hasAuthorship W2000712914A5031357902 @default.
- W2000712914 hasAuthorship W2000712914A5032155136 @default.
- W2000712914 hasAuthorship W2000712914A5035459706 @default.
- W2000712914 hasAuthorship W2000712914A5053320499 @default.
- W2000712914 hasAuthorship W2000712914A5084226421 @default.
- W2000712914 hasConcept C111472728 @default.
- W2000712914 hasConcept C138885662 @default.
- W2000712914 hasConcept C185592680 @default.
- W2000712914 hasConcept C2778004101 @default.
- W2000712914 hasConcept C55493867 @default.
- W2000712914 hasConcept C556039675 @default.
- W2000712914 hasConcept C71924100 @default.
- W2000712914 hasConcept C89611455 @default.
- W2000712914 hasConceptScore W2000712914C111472728 @default.
- W2000712914 hasConceptScore W2000712914C138885662 @default.
- W2000712914 hasConceptScore W2000712914C185592680 @default.
- W2000712914 hasConceptScore W2000712914C2778004101 @default.
- W2000712914 hasConceptScore W2000712914C55493867 @default.
- W2000712914 hasConceptScore W2000712914C556039675 @default.
- W2000712914 hasConceptScore W2000712914C71924100 @default.
- W2000712914 hasConceptScore W2000712914C89611455 @default.
- W2000712914 hasIssue "1" @default.
- W2000712914 hasLocation W20007129141 @default.
- W2000712914 hasOpenAccess W2000712914 @default.
- W2000712914 hasPrimaryLocation W20007129141 @default.
- W2000712914 hasRelatedWork W1917715448 @default.
- W2000712914 hasRelatedWork W2108976683 @default.
- W2000712914 hasRelatedWork W2184358985 @default.
- W2000712914 hasRelatedWork W2187037766 @default.
- W2000712914 hasRelatedWork W2264718782 @default.
- W2000712914 hasRelatedWork W2362029471 @default.
- W2000712914 hasRelatedWork W2389623387 @default.
- W2000712914 hasRelatedWork W2622846185 @default.
- W2000712914 hasRelatedWork W2764841094 @default.
- W2000712914 hasRelatedWork W2182949346 @default.
- W2000712914 hasVolume "57" @default.
- W2000712914 isParatext "false" @default.
- W2000712914 isRetracted "false" @default.
- W2000712914 magId "2000712914" @default.
- W2000712914 workType "article" @default.