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- W2000713410 abstract "The relation between impedance change and the location and magnitude of a tonic synaptic conductance was examined in compartmental motoneuron models based on previously published data. The dependency of motoneuron impedance on system time constant (τ), electrotonic length (L), and dendritic-to-somatic conductance ratio (ρ) was examined, showing that the relation between impedance phase and ρ differed markedly between models with uniform and nonuniform membrane resistivity. Dendritic synaptic conductances decreased impedance magnitude at low frequencies; at higher frequencies, impedance magnitude increased. The frequency at which the change in impedance magnitude reversed from a decrease to an increase—the reversal frequency, F r —was a good estimator of electrotonic synaptic location. A measure of the average normalized impedance change at frequencies less than F r , cuΔZ, estimated relative synaptic conductance. F r and cuΔZ provided useful estimates of synaptic location and conductance in models with nonuniform (step, sigmoidal) and uniform membrane resistivity. F r also provided good estimates of spatial synaptic location on the equivalent cable in both step and sigmoidal models. Variability in relations between F r , cuΔZ, and conductance location and magnitude between neurons was reduced by normalization with ρ and τ. The effects on F r and cuΔZ of noise in experimental recordings, different synaptic distributions, and voltage-dependent conductances were also assessed. This study indicates that location and conductance of tonic dendritic conductances can be estimated from F r , cuΔZ, and basic electrotonic motoneuron parameters with the exercise of suitable precautions." @default.
- W2000713410 created "2016-06-24" @default.
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- W2000713410 date "2004-09-01" @default.
- W2000713410 modified "2023-09-25" @default.
- W2000713410 title "Determination of the Location and Magnitude of Synaptic Conductance Changes in Spinal Motoneurons by Impedance Measurements" @default.
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- W2000713410 doi "https://doi.org/10.1152/jn.00873.2003" @default.
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