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- W2000714100 abstract "Epithelial-mesenchymal interactions mediated by soluble growth factors determine the evolution of vertebrate lung physiology, including development, homeostasis, and repair. The final common pathway for all of these positively adaptive properties of the lung is the expression of epithelial parathyroid-hormone-related protein, and its binding to its receptor on the mesenchyme, inducing PPARγ expression by lipofibroblasts. Lipofibroblasts then produce leptin, which binds to alveolar type II cells, stimulating their production of surfactant, which is necessary for both evolutionary and physiologic adaptation to atmospheric oxygen from fish to man. A wide variety of molecular insults disrupt such highly evolved physiologic cell-cell interactions, ranging from overdistention to oxidants, infection, and nicotine, all of which predictably cause loss of mesenchymal peroxisome-proliferator-activated receptor gamma (PPARγ) expression and the transdifferentiation of lipofibroblasts to myofibroblasts, the signature cell type for lung fibrosis. By exploiting such deep cell-molecular functional homologies as targets for leveraging lung homeostasis, we have discovered that we can effectively prevent and/or reverse the deleterious effects of these pathogenic agents, demonstrating the utility of evolutionary biology for the prevention and treatment of chronic lung disease. By understanding mechanisms of health and disease as an evolutionary continuum rather than as dissociated processes, we can evolve predictive medicine." @default.
- W2000714100 created "2016-06-24" @default.
- W2000714100 creator A5056130715 @default.
- W2000714100 creator A5081473027 @default.
- W2000714100 date "2012-01-01" @default.
- W2000714100 modified "2023-10-15" @default.
- W2000714100 title "PPAR<i>γ</i>Signaling Mediates the Evolution, Development, Homeostasis, and Repair of the Lung" @default.
- W2000714100 cites W1545536250 @default.
- W2000714100 cites W1554508620 @default.
- W2000714100 cites W1647126819 @default.
- W2000714100 cites W1855993559 @default.
- W2000714100 cites W1972446219 @default.
- W2000714100 cites W1972541273 @default.
- W2000714100 cites W1974207629 @default.
- W2000714100 cites W1975011739 @default.
- W2000714100 cites W1975206045 @default.
- W2000714100 cites W1976059330 @default.
- W2000714100 cites W1978125779 @default.
- W2000714100 cites W1979225592 @default.
- W2000714100 cites W1990327748 @default.
- W2000714100 cites W1993007476 @default.
- W2000714100 cites W1998733764 @default.
- W2000714100 cites W1999102228 @default.
- W2000714100 cites W1999438839 @default.
- W2000714100 cites W2004829388 @default.
- W2000714100 cites W2010024585 @default.
- W2000714100 cites W2013766379 @default.
- W2000714100 cites W2025283490 @default.
- W2000714100 cites W2028986797 @default.
- W2000714100 cites W2029873688 @default.
- W2000714100 cites W2030592938 @default.
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- W2000714100 cites W2057048199 @default.
- W2000714100 cites W2057772566 @default.
- W2000714100 cites W2058247847 @default.
- W2000714100 cites W2058882812 @default.
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- W2000714100 cites W2060740748 @default.
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- W2000714100 cites W2097411478 @default.
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- W2000714100 doi "https://doi.org/10.1155/2012/289867" @default.
- W2000714100 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3390135" @default.
- W2000714100 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22792087" @default.
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