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- W2000714199 abstract "Abstract Antisense oligonucleotides directed against HSV- 1 immediate early gene mRNA were synthesized with replacement of the internal pyrimidine nucleotides by the corresponding 5-(l-hexynyl) analogues and with end-capping by phosphorothioates. These compounds were found to have improved binding affinity, increased stability towards nucleases and enhanced antiviral activity in a cell culture assay." @default.
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- W2000714199 date "1997-07-01" @default.
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- W2000714199 title "Enhanced Biological Activity of Antisense Oligonucleotides Containing 5-(1-Hexynyl)-substituted Pyrimidine Nucleotides" @default.
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- W2000714199 doi "https://doi.org/10.1080/07328319708006262" @default.
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