Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000714496> ?p ?o ?g. }
- W2000714496 endingPage "302" @default.
- W2000714496 startingPage "296" @default.
- W2000714496 abstract "In the last decade, there was the seminal discovery of melanopsin-expressing retinal ganglion cells (mRGCs) as a new class of photoreceptors that subserve the photoentrainment of circadian rhythms and other non-image forming functions of the eye. Since then, there has been a growing research interest on these cells, mainly focused on animal models. Only recently, a few studies have started to address the relevance of the mRGC system in humans and related diseases. We recently discovered that mRGCs resist neurodegeneration in two inherited mitochondrial disorders that cause blindness, i.e. Leber hereditary optic neuropathy and dominant optic atrophy. The mechanism leading to mRGCs sparing in these blinding disorders, characterized by extensive and selective loss of RGCs, is currently unknown and under investigation. Other studies reported on mRGCs in glaucoma, on genetic variation of the melanopsin gene (OPN4) in seasonal affective disorder and on the role of mRGCs in migraineous photophobia. Our own data and studies from others have shown a significant reduction of mRGCs with aging. We anticipate that these studies will lead to many other investigations addressing the role of mRGCs and circadian photoreception in the pathogenesis of circadian and sleep abnormalities in neurodegenerative disorders." @default.
- W2000714496 created "2016-06-24" @default.
- W2000714496 creator A5014136091 @default.
- W2000714496 creator A5037098482 @default.
- W2000714496 creator A5039910421 @default.
- W2000714496 creator A5048398288 @default.
- W2000714496 creator A5065390232 @default.
- W2000714496 creator A5070622522 @default.
- W2000714496 date "2011-01-01" @default.
- W2000714496 modified "2023-10-16" @default.
- W2000714496 title "Melanopsin-expressing retinal ganglion cells: implications for human diseases" @default.
- W2000714496 cites W1480559618 @default.
- W2000714496 cites W1481969699 @default.
- W2000714496 cites W1488048016 @default.
- W2000714496 cites W1535154404 @default.
- W2000714496 cites W1588003045 @default.
- W2000714496 cites W1895211345 @default.
- W2000714496 cites W1964052956 @default.
- W2000714496 cites W1966147077 @default.
- W2000714496 cites W1966929727 @default.
- W2000714496 cites W1967340734 @default.
- W2000714496 cites W1971124135 @default.
- W2000714496 cites W1971956838 @default.
- W2000714496 cites W1974899081 @default.
- W2000714496 cites W1977316202 @default.
- W2000714496 cites W1983875092 @default.
- W2000714496 cites W1985087876 @default.
- W2000714496 cites W1988222262 @default.
- W2000714496 cites W1988983976 @default.
- W2000714496 cites W1989616930 @default.
- W2000714496 cites W1991052335 @default.
- W2000714496 cites W1992420220 @default.
- W2000714496 cites W1996297656 @default.
- W2000714496 cites W1996384089 @default.
- W2000714496 cites W2003302378 @default.
- W2000714496 cites W2004381001 @default.
- W2000714496 cites W2004782810 @default.
- W2000714496 cites W2004874781 @default.
- W2000714496 cites W2005726640 @default.
- W2000714496 cites W2008213690 @default.
- W2000714496 cites W2009077913 @default.
- W2000714496 cites W2010517665 @default.
- W2000714496 cites W2011770871 @default.
- W2000714496 cites W2012020760 @default.
- W2000714496 cites W2013935903 @default.
- W2000714496 cites W2015290866 @default.
- W2000714496 cites W2018398696 @default.
- W2000714496 cites W2019885109 @default.
- W2000714496 cites W2021160835 @default.
- W2000714496 cites W2021738998 @default.
- W2000714496 cites W2022197238 @default.
- W2000714496 cites W2035853180 @default.
- W2000714496 cites W2038854117 @default.
- W2000714496 cites W2039209617 @default.
- W2000714496 cites W2040982608 @default.
- W2000714496 cites W2043842765 @default.
- W2000714496 cites W2047678578 @default.
- W2000714496 cites W2048965827 @default.
- W2000714496 cites W2056888759 @default.
- W2000714496 cites W2057266151 @default.
- W2000714496 cites W2058837644 @default.
- W2000714496 cites W2060660675 @default.
- W2000714496 cites W2062507976 @default.
- W2000714496 cites W2064791649 @default.
- W2000714496 cites W2065911402 @default.
- W2000714496 cites W2067871353 @default.
- W2000714496 cites W2068259240 @default.
- W2000714496 cites W2069342665 @default.
- W2000714496 cites W2070154168 @default.
- W2000714496 cites W2072018453 @default.
- W2000714496 cites W2075562407 @default.
- W2000714496 cites W2081289748 @default.
- W2000714496 cites W2084250026 @default.
- W2000714496 cites W2085483223 @default.
- W2000714496 cites W2088682369 @default.
- W2000714496 cites W2090497649 @default.
- W2000714496 cites W2091263728 @default.
- W2000714496 cites W2092510003 @default.
- W2000714496 cites W2093996130 @default.
- W2000714496 cites W2094467372 @default.
- W2000714496 cites W2105350887 @default.
- W2000714496 cites W2105604325 @default.
- W2000714496 cites W2105948530 @default.
- W2000714496 cites W2107550000 @default.
- W2000714496 cites W2107877547 @default.
- W2000714496 cites W2113049952 @default.
- W2000714496 cites W2115908598 @default.
- W2000714496 cites W2121470947 @default.
- W2000714496 cites W2125102656 @default.
- W2000714496 cites W2125964836 @default.
- W2000714496 cites W2126432711 @default.
- W2000714496 cites W2130524075 @default.
- W2000714496 cites W2133652633 @default.
- W2000714496 cites W2136149869 @default.
- W2000714496 cites W2139425600 @default.
- W2000714496 cites W2147949992 @default.
- W2000714496 cites W2149502603 @default.
- W2000714496 cites W2151131721 @default.