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- W2000714566 abstract "This paper investigates the outcome using different dose/fractionation schedules in high dose rate (HDR) post-operative vaginal vault radiotherapy in patients with low to intermediate risk endometrial cancer.The world literature was reviewed and thirteen series were analyzed representing 1800 cases.A total of 12 vaginal vault recurrences were identified representing an overall vaginal control rate of 99.3%. A wide range of dose fractionation schedules and techniques have been reported. In order to analyze a dose response relationship for tumor control and complications, the biologically effective doses to the tumor and late responding tissues were calculated using the linear quadratic model. A threshold was identified for complications, but not vaginal control. While dose fractionation schedules that delivered a biologically effective dose to the late responding tissues in excess of 100 Gy(3) (LQED=60 Gy) predicted for late complications, dose fractionation schedules that delivered a modest dose to the vaginal surface (50 Gy(10) or LQED=30 Gy) appeared tumoricidal with vaginal control rates of at least 98%.By using convenient, modest dose fractionation schedules, HDR vaginal vault - brachytherapy yields very high local control and extremely low morbidity rates." @default.
- W2000714566 created "2016-06-24" @default.
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- W2000714566 date "2000-07-01" @default.
- W2000714566 modified "2023-09-29" @default.
- W2000714566 title "Post-operative high dose rate brachytherapy in patients with low to intermediate risk endometrial cancer" @default.
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- W2000714566 doi "https://doi.org/10.1016/s0167-8140(00)00171-7" @default.
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