Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000715091> ?p ?o ?g. }
- W2000715091 endingPage "214" @default.
- W2000715091 startingPage "207" @default.
- W2000715091 abstract "Despite longstanding efforts in basic research and clinical studies, the prognosis for patients with acute myeloid leukemia (AML) remains poor. About half of the patients are not medically fit for intensive induction therapy to induce a complete remission and are treated with palliative treatment concepts. The patients medically fit for intensive induction therapy have a high complete remission rate but the majority suffers from relapse due to chemo-refractory leukemic cells. Allogeneic stem cell transplantation as post-remission therapy can significantly reduce the likelihood of relapse, but it is associated with a high rate of morbidity and mortality. Novel therapeutic concepts are therefore urgently sought after. During recent years, the focus has shifted towards the development of novel immunotherapeutic strategies. Some of the most promising are drug-conjugated monoclonal antibodies, T-cell engaging antibody constructs, adoptive transfer with chimeric antigen receptor (CAR) T cells, and dendritic cell vaccination. Here, we review recent progress in these four fields and speculate about the optimal time points during the course of AML treatment for their application." @default.
- W2000715091 created "2016-06-24" @default.
- W2000715091 creator A5003069482 @default.
- W2000715091 creator A5069712978 @default.
- W2000715091 creator A5073691481 @default.
- W2000715091 creator A5089965167 @default.
- W2000715091 date "2015-07-01" @default.
- W2000715091 modified "2023-10-03" @default.
- W2000715091 title "Immunotherapy for Acute Myeloid Leukemia" @default.
- W2000715091 cites W1547799563 @default.
- W2000715091 cites W1556454749 @default.
- W2000715091 cites W1594920269 @default.
- W2000715091 cites W1840766718 @default.
- W2000715091 cites W1963522404 @default.
- W2000715091 cites W1964969705 @default.
- W2000715091 cites W1966327132 @default.
- W2000715091 cites W1967995010 @default.
- W2000715091 cites W1976187277 @default.
- W2000715091 cites W1980868141 @default.
- W2000715091 cites W1990553375 @default.
- W2000715091 cites W1991644988 @default.
- W2000715091 cites W1992291725 @default.
- W2000715091 cites W1993649303 @default.
- W2000715091 cites W1994448489 @default.
- W2000715091 cites W1998307950 @default.
- W2000715091 cites W1999212901 @default.
- W2000715091 cites W2004004651 @default.
- W2000715091 cites W2004037261 @default.
- W2000715091 cites W2008748351 @default.
- W2000715091 cites W2009348430 @default.
- W2000715091 cites W2013971016 @default.
- W2000715091 cites W2014357452 @default.
- W2000715091 cites W2014751400 @default.
- W2000715091 cites W2016783460 @default.
- W2000715091 cites W2022881751 @default.
- W2000715091 cites W2023068069 @default.
- W2000715091 cites W2025338891 @default.
- W2000715091 cites W2028713402 @default.
- W2000715091 cites W2029963293 @default.
- W2000715091 cites W2030249962 @default.
- W2000715091 cites W2038414910 @default.
- W2000715091 cites W2038676366 @default.
- W2000715091 cites W2038719843 @default.
- W2000715091 cites W2041164834 @default.
- W2000715091 cites W2044131792 @default.
- W2000715091 cites W2047205338 @default.
- W2000715091 cites W2050949125 @default.
- W2000715091 cites W2052690356 @default.
- W2000715091 cites W2061528942 @default.
- W2000715091 cites W2064888191 @default.
- W2000715091 cites W2065165068 @default.
- W2000715091 cites W2065709542 @default.
- W2000715091 cites W2066915026 @default.
- W2000715091 cites W2066915867 @default.
- W2000715091 cites W2069315694 @default.
- W2000715091 cites W2077994554 @default.
- W2000715091 cites W2086766201 @default.
- W2000715091 cites W2087665046 @default.
- W2000715091 cites W2089559050 @default.
- W2000715091 cites W2097995306 @default.
- W2000715091 cites W2098298980 @default.
- W2000715091 cites W2099570622 @default.
- W2000715091 cites W2100731432 @default.
- W2000715091 cites W2103349915 @default.
- W2000715091 cites W2103959341 @default.
- W2000715091 cites W2105400883 @default.
- W2000715091 cites W2111742915 @default.
- W2000715091 cites W2112998845 @default.
- W2000715091 cites W2115492737 @default.
- W2000715091 cites W2116858301 @default.
- W2000715091 cites W2118241155 @default.
- W2000715091 cites W2118820872 @default.
- W2000715091 cites W2127568389 @default.
- W2000715091 cites W2130011407 @default.
- W2000715091 cites W2130185253 @default.
- W2000715091 cites W2130338247 @default.
- W2000715091 cites W2133339821 @default.
- W2000715091 cites W2135435448 @default.
- W2000715091 cites W2137217341 @default.
- W2000715091 cites W2145444883 @default.
- W2000715091 cites W2146862320 @default.
- W2000715091 cites W2156144893 @default.
- W2000715091 cites W2160026729 @default.
- W2000715091 cites W2162578269 @default.
- W2000715091 cites W2169129203 @default.
- W2000715091 cites W2169961966 @default.
- W2000715091 cites W2170513194 @default.
- W2000715091 doi "https://doi.org/10.1053/j.seminhematol.2015.03.006" @default.
- W2000715091 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26111468" @default.
- W2000715091 hasPublicationYear "2015" @default.
- W2000715091 type Work @default.
- W2000715091 sameAs 2000715091 @default.
- W2000715091 citedByCount "44" @default.
- W2000715091 countsByYear W20007150912015 @default.
- W2000715091 countsByYear W20007150912016 @default.
- W2000715091 countsByYear W20007150912017 @default.
- W2000715091 countsByYear W20007150912018 @default.
- W2000715091 countsByYear W20007150912019 @default.