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• W2000716207 abstract "Automatic anatomical segmentation of magnetic resonance human brain images has been shown to be accurate and robust when based on multiple atlases that encompass the anatomical variability of the cohort of subjects. We observed that the method tends to fail when the segmentation target shows ventricular enlargement that is not captured by the atlas database. By incorporating tissue classification information into the image registration process, we aimed to increase the robustness of the method. For testing, subjects who participated in the Oxford Project to Investigate Memory and Aging (OPTIMA) and the Alzheimer's Disease Neuroimaging Initiative (ADNI) were selected for ventriculomegaly. Segmentation quality was substantially improved in the ventricles and surrounding structures (9/9 successes on visual rating versus 4/9 successes using the baseline method). In addition, the modification resulted in a significant increase of segmentation accuracy in healthy subjects' brain images. Hippocampal segmentation results in a group of patients with temporal lobe epilepsy were near identical with both approaches. The modified approach (MAPER, multi-atlas propagation with enhanced registration) extends the applicability of multi-atlas based automatic whole-brain segmentation to subjects with ventriculomegaly, as seen in normal aging as well as in numerous neurodegenerative diseases." @default.
• W2000716207 created "2016-06-24" @default.
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• W2000716207 date "2010-05-01" @default.
• W2000716207 modified "2023-10-16" @default.
• W2000716207 title "Improving intersubject image registration using tissue-class information benefits robustness and accuracy of multi-atlas based anatomical segmentation" @default.
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• W2000716207 doi "https://doi.org/10.1016/j.neuroimage.2010.01.072" @default.
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