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• W2000716491 abstract "G-protein-coupled receptors (GPCRs) are the largest family of eukaryotic plasma membrane receptors, and are responsible for the majority of cellular responses to external signals. GPCRs share a common architecture comprising seven transmembrane (TM) helices. Binding of an activating ligand enables the receptor to catalyze the exchange of GTP for GDP in a heterotrimeric G protein. GPCRs are in a conformational equilibrium between inactive and activating states. Crystallographic and spectroscopic studies of the visual pigment rhodopsin and two β-adrenergic receptors have defined some of the conformational changes associated with activation." @default.
• W2000716491 created "2016-06-24" @default.
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• W2000716491 date "2008-12-01" @default.
• W2000716491 modified "2023-10-16" @default.
• W2000716491 title "Structural insights into G-protein-coupled receptor activation" @default.
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• W2000716491 doi "https://doi.org/10.1016/j.sbi.2008.09.010" @default.
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