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- W2000716584 abstract "In Drosophila melanogaster the rudimentary locus encodes for a multifunctional protein catalyzing the first three enzymatic activities of pyrimidine biosynthesis. Cell lines were selected which were resistant to PALA (N-(phosphonoacetyl)-L-aspartate), a specific inhibitor of aspartate transcarbamylase, the second enzyme of this pathway. In a cell line where the enzyme production is increased 5 times, Southern blot analyses show that the rudimentary gene and surrounding regions are amplified about 5 times. In this case gene amplification could therefore account for the observed enzyme overproduction." @default.
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- W2000716584 date "1983-10-17" @default.
- W2000716584 modified "2023-09-25" @default.
- W2000716584 title "Amplification of the rudimentary gene in a PALA-resistantDrosophilacell line" @default.
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- W2000716584 doi "https://doi.org/10.1016/0014-5793(83)80790-x" @default.
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