FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000717024> ?p ?o ?g. }

• W2000717024 abstract "Comparison of recent patterns of recombination derived from linkage maps to historical patterns of recombination from linkage disequilibrium (LD) could help identify genomic regions affected by strong artificial selection, appearing as reduced recent recombination. Norwegian Red cattle (NRF) make an interesting case study for investigating these patterns as it is an admixed breed with an extensively recorded pedigree. NRF have been under strong artificial selection for traits such as milk and meat production, fertility and health. While measures of LD is also crucial for determining the number of markers required for association mapping studies, estimates of recombination rate can be used to assess quality of genomic assemblies.A dataset containing more than 17,000 genome-wide distributed SNPs and 2600 animals was used to assess recombination rates and LD in NRF. Although low LD measured by r2 was observed in NRF relative to some of the breeds from which this breed originates, reports from breeds other than those assessed in this study have described more rapid decline in r2 at short distances than what was found in NRF. Rate of decline in r2 for NRF suggested that to obtain an expected r2 between markers and a causal polymorphism of at least 0.5 for genome-wide association studies, approximately one SNP every 15 kb or a total of 200,000 SNPs would be required. For well known quantitative trait loci (QTLs) for milk production traits on Bos Taurus chromosomes 1, 6 and 20, map length based on historic recombination was greater than map length based on recent recombination in NRF. Further, positions for 130 previously unpositioned contigs from assembly of the bovine genome sequence (Btau_4.0) found using comparative sequence analysis were validated by linkage analysis, and 28% of these positions corresponded to extreme values of population recombination rate.While LD is reduced in NRF compared to some of the breeds from which this admixed breed originated, it is elevated over short distances compared to some other cattle breeds. Genomic regions in NRF where map length based on historic recombination was greater than map length based on recent recombination coincided with some well known QTL regions for milk production traits. Linkage analysis in combination with comparative sequence analysis and detection of regions with extreme values of population recombination rate proved to be valuable for detecting problematic regions in the Btau_4.0 genome assembly." @default.
• W2000717024 created "2016-06-24" @default.
• W2000717024 creator A5017989966 @default.
• W2000717024 creator A5052123252 @default.
• W2000717024 creator A5058907257 @default.
• W2000717024 creator A5074648072 @default.
• W2000717024 creator A5085842865 @default.
• W2000717024 date "2011-01-14" @default.
• W2000717024 modified "2023-10-06" @default.
• W2000717024 title "Recent and historical recombination in the admixed Norwegian Red cattle breed" @default.
• W2000717024 cites W1924262429 @default.
• W2000717024 cites W1935910619 @default.
• W2000717024 cites W1982733535 @default.
• W2000717024 cites W1984921840 @default.
• W2000717024 cites W1986955696 @default.
• W2000717024 cites W1987882116 @default.
• W2000717024 cites W1988896526 @default.
• W2000717024 cites W2002307095 @default.
• W2000717024 cites W2005935256 @default.
• W2000717024 cites W2006189274 @default.
• W2000717024 cites W2015270113 @default.
• W2000717024 cites W2031669852 @default.
• W2000717024 cites W2034159975 @default.
• W2000717024 cites W2037217957 @default.
• W2000717024 cites W2042666786 @default.
• W2000717024 cites W2055666215 @default.
• W2000717024 cites W2060480089 @default.
• W2000717024 cites W2061941091 @default.
• W2000717024 cites W2067569885 @default.
• W2000717024 cites W2078433308 @default.
• W2000717024 cites W2080347313 @default.
• W2000717024 cites W2091498804 @default.
• W2000717024 cites W2096991924 @default.
• W2000717024 cites W2099568121 @default.
• W2000717024 cites W2103106090 @default.
• W2000717024 cites W2104146295 @default.
• W2000717024 cites W2104703917 @default.
• W2000717024 cites W2104743461 @default.
• W2000717024 cites W2105350629 @default.
• W2000717024 cites W2108169091 @default.
• W2000717024 cites W2110755408 @default.
• W2000717024 cites W2114765236 @default.
• W2000717024 cites W2121286926 @default.
• W2000717024 cites W2121681870 @default.
• W2000717024 cites W2121954964 @default.
• W2000717024 cites W2126896706 @default.
• W2000717024 cites W2129454675 @default.
• W2000717024 cites W2129607209 @default.
• W2000717024 cites W2129987350 @default.
• W2000717024 cites W2130248958 @default.
• W2000717024 cites W2138311236 @default.
• W2000717024 cites W2142417092 @default.
• W2000717024 cites W2144870508 @default.
• W2000717024 cites W2152696799 @default.
• W2000717024 cites W2157211770 @default.
• W2000717024 cites W2159349760 @default.
• W2000717024 cites W2162530578 @default.
• W2000717024 cites W2162919721 @default.
• W2000717024 cites W2283975364 @default.
• W2000717024 doi "https://doi.org/10.1186/1471-2164-12-33" @default.
• W2000717024 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3030550" @default.
• W2000717024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21232164" @default.
• W2000717024 hasPublicationYear "2011" @default.
• W2000717024 type Work @default.
• W2000717024 sameAs 2000717024 @default.
• W2000717024 citedByCount "10" @default.
• W2000717024 countsByYear W20007170242012 @default.
• W2000717024 countsByYear W20007170242013 @default.
• W2000717024 countsByYear W20007170242015 @default.
• W2000717024 countsByYear W20007170242016 @default.
• W2000717024 countsByYear W20007170242017 @default.
• W2000717024 countsByYear W20007170242020 @default.
• W2000717024 countsByYear W20007170242023 @default.
• W2000717024 crossrefType "journal-article" @default.
• W2000717024 hasAuthorship W2000717024A5017989966 @default.
• W2000717024 hasAuthorship W2000717024A5052123252 @default.
• W2000717024 hasAuthorship W2000717024A5058907257 @default.
• W2000717024 hasAuthorship W2000717024A5074648072 @default.
• W2000717024 hasAuthorship W2000717024A5085842865 @default.
• W2000717024 hasBestOaLocation W20007170241 @default.
• W2000717024 hasConcept C104317684 @default.
• W2000717024 hasConcept C135763542 @default.
• W2000717024 hasConcept C141231307 @default.
• W2000717024 hasConcept C153209595 @default.
• W2000717024 hasConcept C156695909 @default.
• W2000717024 hasConcept C186413461 @default.
• W2000717024 hasConcept C2776116246 @default.
• W2000717024 hasConcept C2776482104 @default.
• W2000717024 hasConcept C35605836 @default.
• W2000717024 hasConcept C54355233 @default.
• W2000717024 hasConcept C81941488 @default.
• W2000717024 hasConcept C86803240 @default.
• W2000717024 hasConceptScore W2000717024C104317684 @default.
• W2000717024 hasConceptScore W2000717024C135763542 @default.
• W2000717024 hasConceptScore W2000717024C141231307 @default.
• W2000717024 hasConceptScore W2000717024C153209595 @default.
• W2000717024 hasConceptScore W2000717024C156695909 @default.
• W2000717024 hasConceptScore W2000717024C186413461 @default.
• W2000717024 hasConceptScore W2000717024C2776116246 @default.
• W2000717024 hasConceptScore W2000717024C2776482104 @default.

• next