Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000717084> ?p ?o ?g. }
- W2000717084 endingPage "263.e5" @default.
- W2000717084 startingPage "257" @default.
- W2000717084 abstract "Mast cells contribute to the pathophysiology of asthma with the sustained release of both preformed and newly generated mediators in response to allergens and other diverse stimuli. Stem cell factor (SCF) is the key human mast cell growth factor, but also primes mast cells for mediator release. SCF expression is markedly increased in asthmatic airways. Short-acting beta(2)-adrenoceptor drugs such as albuterol inhibit human lung mast cell (HLMC) degranulation in vitro in the absence of SCF, but their effect in the presence of SCF is not known.The aim of this study was to elucidate the effects of albuterol on HLMC function in the presence of SCF.Mediator release and K(Ca)3.1 ion channel activity were analyzed in purified HLMC. Intracellular signalling and beta(2)-adrenoceptor phosphorylation and internalization were analyzed in the HMC-1 human mast cell line.beta(2)-Adrenoceptor agonist-dependent inhibition of K(Ca)3.1 ion channels and HLMC mediator release was markedly attenuated in the presence of SCF. Remarkably, albuterol actually potentiated IgE-induced histamine release in a dose-dependent manner when both SCF and IgE were present. These effects were related to the SCF-dependent phosphorylation of Tyr350 on the beta(2)-adrenoceptor with immediate uncoupling of the receptor followed by receptor internalization.The potentially beneficial effects of beta(2)-adrenoceptor agonists in asthmatic airways may be blunted as a result of the high concentrations of SCF present." @default.
- W2000717084 created "2016-06-24" @default.
- W2000717084 creator A5000711773 @default.
- W2000717084 creator A5002379615 @default.
- W2000717084 creator A5017323068 @default.
- W2000717084 creator A5043495928 @default.
- W2000717084 creator A5049159599 @default.
- W2000717084 creator A5061501873 @default.
- W2000717084 creator A5079628483 @default.
- W2000717084 date "2010-01-01" @default.
- W2000717084 modified "2023-10-17" @default.
- W2000717084 title "Counterregulation of β2-adrenoceptor function in human mast cells by stem cell factor" @default.
- W2000717084 cites W1509033214 @default.
- W2000717084 cites W169445797 @default.
- W2000717084 cites W1764319705 @default.
- W2000717084 cites W1923064046 @default.
- W2000717084 cites W1936935448 @default.
- W2000717084 cites W1965240735 @default.
- W2000717084 cites W1967959196 @default.
- W2000717084 cites W1973148624 @default.
- W2000717084 cites W1974430704 @default.
- W2000717084 cites W1981984902 @default.
- W2000717084 cites W1988802336 @default.
- W2000717084 cites W1994745317 @default.
- W2000717084 cites W1998791810 @default.
- W2000717084 cites W2006439234 @default.
- W2000717084 cites W2007628759 @default.
- W2000717084 cites W2009933260 @default.
- W2000717084 cites W2013464008 @default.
- W2000717084 cites W2015427101 @default.
- W2000717084 cites W2021033207 @default.
- W2000717084 cites W2027552024 @default.
- W2000717084 cites W2033128560 @default.
- W2000717084 cites W2036611467 @default.
- W2000717084 cites W2037293320 @default.
- W2000717084 cites W2039357329 @default.
- W2000717084 cites W2049374822 @default.
- W2000717084 cites W2061261377 @default.
- W2000717084 cites W2079484889 @default.
- W2000717084 cites W2081137597 @default.
- W2000717084 cites W2094739393 @default.
- W2000717084 cites W2110691844 @default.
- W2000717084 cites W2111474925 @default.
- W2000717084 cites W2112849484 @default.
- W2000717084 cites W2116003183 @default.
- W2000717084 cites W2125864071 @default.
- W2000717084 cites W2132334122 @default.
- W2000717084 cites W2134711776 @default.
- W2000717084 cites W2155589243 @default.
- W2000717084 cites W2156015098 @default.
- W2000717084 cites W2159356105 @default.
- W2000717084 cites W2163441905 @default.
- W2000717084 cites W2168960379 @default.
- W2000717084 cites W223433465 @default.
- W2000717084 cites W2331287401 @default.
- W2000717084 cites W38779928 @default.
- W2000717084 cites W4313341535 @default.
- W2000717084 doi "https://doi.org/10.1016/j.jaci.2009.08.020" @default.
- W2000717084 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19864009" @default.
- W2000717084 hasPublicationYear "2010" @default.
- W2000717084 type Work @default.
- W2000717084 sameAs 2000717084 @default.
- W2000717084 citedByCount "21" @default.
- W2000717084 countsByYear W20007170842012 @default.
- W2000717084 countsByYear W20007170842014 @default.
- W2000717084 countsByYear W20007170842015 @default.
- W2000717084 countsByYear W20007170842016 @default.
- W2000717084 countsByYear W20007170842017 @default.
- W2000717084 countsByYear W20007170842018 @default.
- W2000717084 countsByYear W20007170842020 @default.
- W2000717084 countsByYear W20007170842021 @default.
- W2000717084 crossrefType "journal-article" @default.
- W2000717084 hasAuthorship W2000717084A5000711773 @default.
- W2000717084 hasAuthorship W2000717084A5002379615 @default.
- W2000717084 hasAuthorship W2000717084A5017323068 @default.
- W2000717084 hasAuthorship W2000717084A5043495928 @default.
- W2000717084 hasAuthorship W2000717084A5049159599 @default.
- W2000717084 hasAuthorship W2000717084A5061501873 @default.
- W2000717084 hasAuthorship W2000717084A5079628483 @default.
- W2000717084 hasConcept C109159458 @default.
- W2000717084 hasConcept C1122143 @default.
- W2000717084 hasConcept C126322002 @default.
- W2000717084 hasConcept C134018914 @default.
- W2000717084 hasConcept C139770010 @default.
- W2000717084 hasConcept C141105273 @default.
- W2000717084 hasConcept C159654299 @default.
- W2000717084 hasConcept C170493617 @default.
- W2000717084 hasConcept C185592680 @default.
- W2000717084 hasConcept C2022786 @default.
- W2000717084 hasConcept C203014093 @default.
- W2000717084 hasConcept C2779726688 @default.
- W2000717084 hasConcept C28328180 @default.
- W2000717084 hasConcept C49802076 @default.
- W2000717084 hasConcept C71924100 @default.
- W2000717084 hasConcept C86803240 @default.
- W2000717084 hasConcept C95444343 @default.
- W2000717084 hasConcept C98274493 @default.
- W2000717084 hasConceptScore W2000717084C109159458 @default.