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- W2000719782 abstract "The need to evaluate the potential for new drugs to produce adverse effects on respiratory function in non-clinical safety assessment is based on the known effects of drugs from a variety of pharmacological/therapeutic classes on the respiratory system, the life-threatening consequences of respiratory dysfunction, and compliance with world-wide regulatory safety guidelines. The objective of this article is to provide a brief overview of the functional disorders of the respiratory system and to present the strategy and techniques considered to be most appropriate for detecting and characterizing drug-induced respiratory disorders in non-clinical safety studies." @default.
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- W2000719782 date "2005-09-01" @default.
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- W2000719782 title "Comprehensive non-clinical respiratory evaluation of promising new drugs" @default.
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- W2000719782 doi "https://doi.org/10.1016/j.taap.2005.01.041" @default.
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