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• W2000720616 abstract "A phase II trial was carried out by the Grupo Oncológico Cooperativo del Sur (G.O.C.S.) to assess the efficacy and toxicity of a biochemical modulation of 5-fluorouracil (5-FU) by i.v. pretreatment with interferon (IFN)-α2b in patients with advanced colorectal carcinoma refractory to previous therapy with 5-FU modulated by methotrexate (MTX) or leucovorin (LV) or both. Between January 1993 and October 1995, 34 patients were entered on the study. The treatment was IFN-α2b 5 × 106/m2 IU in a 1-h i.v. infusion, followed immediately by 5-FU 600 mg/m2 i.v. bolus injection. Courses were repeated weekly until observation of progressive disease or severe toxicity. One patient could not be assessed for response. Objective regression was observed in 2 of 33 patients (6%, 95% confidence interval, 0%–l4%). No patient achieved a complete response. Two patients had partial responses (6%). No change was recorded in 14 patients (41%), and progressive disease occurred in 17 (52%). The median time to treatment failure was 3 months, and the median survival was 5 months. Toxicity was within acceptable limits. The main side effects were mucositis and diarrhea. Four episodes of grade 2 stomatitis were observed, causing dosage modifications. The most frequent toxic effects attributable to IFN-α2b were mild fatigue and fever. In conclusion, second-line therapy with i.v. IFN-α2b preceding 5-FU has shown an interesting profile of activity in a patient population with clearly unfavorable characteristics. From this perspective, further appropriately designed studies are needed to identify the greatest potential of IFN-α2b as a modulator of 5-FU." @default.
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• W2000720616 date "1998-08-01" @default.
• W2000720616 modified "2023-09-26" @default.
• W2000720616 title "Biomodulation with Sequential Intravenous IFN-α2b and 5-Fluorouracil as Second-Line Treatment in Patients with Advanced Colorectal Cancer" @default.
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• W2000720616 doi "https://doi.org/10.1089/jir.1998.18.565" @default.
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