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- W2000720913 abstract "To study the regulation of major histocompatibility complex class II antigen by central nervous system cells, the expression of one of these antigens, human leukocyte antigenDR (HLADR) in three human glioblastoma cell lines (HTB14, 16 and 17) and a neuroblastoma cell line (HTB11) was determined. Interferon-γ (IFNγ) induced HTB16 and HTB17 cells to express HLADR, and enhanced the antigen expression in HTB14 cells, but it failed to induce HLADR expression in HTB11 cells. Tumor necrosis factor-α amplified and accelerated the expression of HLADR induced by IFNγ in HTB16 cells. Interleukin-1β, prostaglandin E2 and transforming growth factor-β suppressed IFNγ-induced HLADR expression in HTB16 cells. Several other substances tested did not affect HLADR expression or IFNγ-induced HLADR. These findings confirm that IFNγ plays a role in the regulation of HLADR expression in cells derived from the brain and that some other cytokines modify IFNγ-HLADR interactions." @default.
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- W2000720913 date "1991-12-01" @default.
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- W2000720913 title "Modulation of human leukocyte antigenDR expression in glioblastoma cells by interferon gamma and other cytokines" @default.
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- W2000720913 doi "https://doi.org/10.1016/0165-5728(91)90169-8" @default.
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