FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000722209> ?p ?o ?g. }

• W2000722209 endingPage "99" @default.
• W2000722209 startingPage "93" @default.
• W2000722209 abstract "Intraepithelial migration of lymphoid cells (epitheliotropism) through the basement membrane of the bile duct is a key event in the development of chronic non-suppurative destructive cholangitis (CNSDC) and eventual immune-mediated bile duct loss in primary biliary cirrhosis (PBC). Cell-to-cell and cell-to-extracellular matrix proteins may play an important role in the development of CNSDC. To address the events of epitheliotropism in CNSDC, the expression of cell-matrix adhesion molecules such as integrins alpha1, alpha3, alpha4, alpha5, and alpha6 and the distribution of fibronectin, laminin, and collagen type IV were studied immunohistochemically, with emphasis on both infiltrating lymphocytes and the bile ducts, in frozen sections from 15 PBC cases and 34 controls (chronic viral hepatitis, extrahepatic biliary obstruction, and normal liver). In PBC and chronic viral hepatitis, most of the infiltrating lymphoid cells expressed integrin alpha4, while such expression was less common in extrahepatic biliary obstruction and normal liver. A biliary basement membrane-like structure was delineated by immunostaining of collagen type IV and laminin in PBC and controls. On the basement membrane of CNSDC, fibronectin, a ligand of integrin alpha4, was strongly and frequently expressed in PBC, while such expression on the biliary basement membrane was rare in other controls. These results suggest that increased fibronectin expression on the biliary basement membrane and integrin alpha4-fibronectin interaction facilitate adhesion and the penetration of infiltrating alpha4-expressing lymphocytes into the biliary epithelial layer in PBC." @default.
• W2000722209 created "2016-06-24" @default.
• W2000722209 creator A5001339908 @default.
• W2000722209 creator A5008003570 @default.
• W2000722209 creator A5008794738 @default.
• W2000722209 creator A5029678899 @default.
• W2000722209 creator A5064494964 @default.
• W2000722209 creator A5069672814 @default.
• W2000722209 date "2000-01-01" @default.
• W2000722209 modified "2023-10-05" @default.
• W2000722209 title "Immunohistochemical analysis of cell-matrix adhesion molecules and their ligands in the portal tracts of primary biliary cirrhosis" @default.
• W2000722209 cites W146864571 @default.
• W2000722209 cites W1491088420 @default.
• W2000722209 cites W1530150767 @default.
• W2000722209 cites W1905241259 @default.
• W2000722209 cites W1966286149 @default.
• W2000722209 cites W1975975653 @default.
• W2000722209 cites W1980123888 @default.
• W2000722209 cites W2001539861 @default.
• W2000722209 cites W2006248795 @default.
• W2000722209 cites W2012330543 @default.
• W2000722209 cites W2034475524 @default.
• W2000722209 cites W2035525109 @default.
• W2000722209 cites W2039957315 @default.
• W2000722209 cites W2040027819 @default.
• W2000722209 cites W2044617588 @default.
• W2000722209 cites W2060565237 @default.
• W2000722209 cites W2062582674 @default.
• W2000722209 cites W2072737535 @default.
• W2000722209 cites W2078610347 @default.
• W2000722209 cites W2090861902 @default.
• W2000722209 cites W2096428903 @default.
• W2000722209 cites W2108617074 @default.
• W2000722209 cites W2119741323 @default.
• W2000722209 cites W2147474072 @default.
• W2000722209 cites W2170412254 @default.
• W2000722209 doi "https://doi.org/10.1002/(sici)1096-9896(200001)190:1<93::aid-path507>3.0.co;2-a" @default.
• W2000722209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10640998" @default.
• W2000722209 hasPublicationYear "2000" @default.
• W2000722209 type Work @default.
• W2000722209 sameAs 2000722209 @default.
• W2000722209 citedByCount "30" @default.
• W2000722209 countsByYear W20007222092012 @default.
• W2000722209 countsByYear W20007222092014 @default.
• W2000722209 countsByYear W20007222092015 @default.
• W2000722209 countsByYear W20007222092018 @default.
• W2000722209 countsByYear W20007222092019 @default.
• W2000722209 countsByYear W20007222092020 @default.
• W2000722209 countsByYear W20007222092022 @default.
• W2000722209 crossrefType "journal-article" @default.
• W2000722209 hasAuthorship W2000722209A5001339908 @default.
• W2000722209 hasAuthorship W2000722209A5008003570 @default.
• W2000722209 hasAuthorship W2000722209A5008794738 @default.
• W2000722209 hasAuthorship W2000722209A5029678899 @default.
• W2000722209 hasAuthorship W2000722209A5064494964 @default.
• W2000722209 hasAuthorship W2000722209A5069672814 @default.
• W2000722209 hasConcept C126322002 @default.
• W2000722209 hasConcept C142724271 @default.
• W2000722209 hasConcept C1491633281 @default.
• W2000722209 hasConcept C16224149 @default.
• W2000722209 hasConcept C189165786 @default.
• W2000722209 hasConcept C195687474 @default.
• W2000722209 hasConcept C203014093 @default.
• W2000722209 hasConcept C2776193487 @default.
• W2000722209 hasConcept C2777107211 @default.
• W2000722209 hasConcept C2779075594 @default.
• W2000722209 hasConcept C2779134260 @default.
• W2000722209 hasConcept C2779777945 @default.
• W2000722209 hasConcept C2779814568 @default.
• W2000722209 hasConcept C2780366471 @default.
• W2000722209 hasConcept C2994419564 @default.
• W2000722209 hasConcept C55493867 @default.
• W2000722209 hasConcept C71924100 @default.
• W2000722209 hasConcept C86492073 @default.
• W2000722209 hasConcept C86803240 @default.
• W2000722209 hasConcept C95444343 @default.
• W2000722209 hasConceptScore W2000722209C126322002 @default.
• W2000722209 hasConceptScore W2000722209C142724271 @default.
• W2000722209 hasConceptScore W2000722209C1491633281 @default.
• W2000722209 hasConceptScore W2000722209C16224149 @default.
• W2000722209 hasConceptScore W2000722209C189165786 @default.
• W2000722209 hasConceptScore W2000722209C195687474 @default.
• W2000722209 hasConceptScore W2000722209C203014093 @default.
• W2000722209 hasConceptScore W2000722209C2776193487 @default.
• W2000722209 hasConceptScore W2000722209C2777107211 @default.
• W2000722209 hasConceptScore W2000722209C2779075594 @default.
• W2000722209 hasConceptScore W2000722209C2779134260 @default.
• W2000722209 hasConceptScore W2000722209C2779777945 @default.
• W2000722209 hasConceptScore W2000722209C2779814568 @default.
• W2000722209 hasConceptScore W2000722209C2780366471 @default.
• W2000722209 hasConceptScore W2000722209C2994419564 @default.
• W2000722209 hasConceptScore W2000722209C55493867 @default.
• W2000722209 hasConceptScore W2000722209C71924100 @default.
• W2000722209 hasConceptScore W2000722209C86492073 @default.
• W2000722209 hasConceptScore W2000722209C86803240 @default.
• W2000722209 hasConceptScore W2000722209C95444343 @default.
• W2000722209 hasIssue "1" @default.
• W2000722209 hasLocation W20007222091 @default.

• next