Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000722430> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2000722430 endingPage "239" @default.
- W2000722430 startingPage "234" @default.
- W2000722430 abstract "Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are shared by excitable cells and seem to be the structural ground for cross-talk between cell-surface and intracellular ionic channels. Our current studies have identified junctophilins (JPs) as members of a novel transmembrane protein family in the junctional membrane complex. Biochemical and gene-knockout studies have suggested that JPs contribute to the formation of the junctional membrane complex by spanning the intracellular store membrane and interacting with the plasma membrane. We report here invertebrate JPs in fruit fly and nematode. Three distinct JP subtype genes are found in the mammalian genome, while a single JP gene exists in either invertebrate genome. Mammalian and invertebrate JPs share characteristic structural features, although some intervening sequences are found in invertebrate JPs. A reporter assay indicated that the JP gene is predominantly activated in muscle cells in nematode. Nematodes, in which expression of JP was inhibited by RNA-mediated interference (RNAi), showed hypolocomotion. Taking account of the cell-type-specific expression and data from previous reports, the hypolocomotion is likely to be due to the deficiency of junctional membrane structures and the resulting reduction of Ca(2+) signaling during excitation-contraction coupling in muscle cells." @default.
- W2000722430 created "2016-06-24" @default.
- W2000722430 creator A5009704292 @default.
- W2000722430 creator A5023883061 @default.
- W2000722430 creator A5024358171 @default.
- W2000722430 creator A5026452337 @default.
- W2000722430 date "2001-11-01" @default.
- W2000722430 modified "2023-09-30" @default.
- W2000722430 title "Important Role of Junctophilin in Nematode Motor Function" @default.
- W2000722430 cites W1647075334 @default.
- W2000722430 cites W1970578796 @default.
- W2000722430 cites W1971255655 @default.
- W2000722430 cites W1977728729 @default.
- W2000722430 cites W2004326327 @default.
- W2000722430 cites W2009452631 @default.
- W2000722430 cites W2018574166 @default.
- W2000722430 cites W2043481572 @default.
- W2000722430 cites W2063081959 @default.
- W2000722430 cites W2073612535 @default.
- W2000722430 cites W2078360969 @default.
- W2000722430 cites W2079637246 @default.
- W2000722430 cites W2080112003 @default.
- W2000722430 cites W2088093088 @default.
- W2000722430 cites W2102066423 @default.
- W2000722430 cites W2122163057 @default.
- W2000722430 cites W2123212170 @default.
- W2000722430 cites W2128270335 @default.
- W2000722430 cites W2128491398 @default.
- W2000722430 cites W2145037154 @default.
- W2000722430 doi "https://doi.org/10.1006/bbrc.2001.5951" @default.
- W2000722430 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11708805" @default.
- W2000722430 hasPublicationYear "2001" @default.
- W2000722430 type Work @default.
- W2000722430 sameAs 2000722430 @default.
- W2000722430 citedByCount "14" @default.
- W2000722430 countsByYear W20007224302018 @default.
- W2000722430 countsByYear W20007224302019 @default.
- W2000722430 countsByYear W20007224302020 @default.
- W2000722430 countsByYear W20007224302021 @default.
- W2000722430 countsByYear W20007224302022 @default.
- W2000722430 countsByYear W20007224302023 @default.
- W2000722430 crossrefType "journal-article" @default.
- W2000722430 hasAuthorship W2000722430A5009704292 @default.
- W2000722430 hasAuthorship W2000722430A5023883061 @default.
- W2000722430 hasAuthorship W2000722430A5024358171 @default.
- W2000722430 hasAuthorship W2000722430A5026452337 @default.
- W2000722430 hasConcept C104317684 @default.
- W2000722430 hasConcept C158617107 @default.
- W2000722430 hasConcept C54355233 @default.
- W2000722430 hasConcept C79879829 @default.
- W2000722430 hasConcept C86803240 @default.
- W2000722430 hasConcept C95444343 @default.
- W2000722430 hasConceptScore W2000722430C104317684 @default.
- W2000722430 hasConceptScore W2000722430C158617107 @default.
- W2000722430 hasConceptScore W2000722430C54355233 @default.
- W2000722430 hasConceptScore W2000722430C79879829 @default.
- W2000722430 hasConceptScore W2000722430C86803240 @default.
- W2000722430 hasConceptScore W2000722430C95444343 @default.
- W2000722430 hasIssue "1" @default.
- W2000722430 hasLocation W20007224301 @default.
- W2000722430 hasLocation W20007224302 @default.
- W2000722430 hasOpenAccess W2000722430 @default.
- W2000722430 hasPrimaryLocation W20007224301 @default.
- W2000722430 hasRelatedWork W2052371969 @default.
- W2000722430 hasRelatedWork W2078527512 @default.
- W2000722430 hasRelatedWork W2098230641 @default.
- W2000722430 hasRelatedWork W2168143869 @default.
- W2000722430 hasRelatedWork W2171277769 @default.
- W2000722430 hasRelatedWork W2890008100 @default.
- W2000722430 hasRelatedWork W2949594890 @default.
- W2000722430 hasRelatedWork W2990070850 @default.
- W2000722430 hasRelatedWork W3009733240 @default.
- W2000722430 hasRelatedWork W3142122528 @default.
- W2000722430 hasVolume "289" @default.
- W2000722430 isParatext "false" @default.
- W2000722430 isRetracted "false" @default.
- W2000722430 magId "2000722430" @default.
- W2000722430 workType "article" @default.