Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000722792> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2000722792 endingPage "137" @default.
- W2000722792 startingPage "127" @default.
- W2000722792 abstract "The clone-forming capacity and level of DNA repair was examined on normal human cells and repair-deficient Xeroderma pigmentosum (XP) fibroblasts exposed to various chemical carcinogens and mutagens. The cultured fibroblasts were treated for 90 min with the carcinogenic and mutagenic 4-nitroquinoline 1-oxide (4NQO), 4-hydroxyaminoquinoline 1-oxide (4HAQO), 2-methyl-4-nitroquinoline 1-oxide (2-Me-4NQO), 3-methyl-4-nitropyridine 1-oxide 3-Me-4NPO) and the non-carcinogenic 6-nitroquinoline 1-oxide (6NQO). The response of the cells to the N-oxides was compared to that induced by the mutagen and carcinogen N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) and UV-irradiation. The XP cells showed (1) a reduced level of DNA repair synthesis when exposed to various carcinogenic N-oxides, (2) no unscheduled DNA synthesis following 6NQO and (3) a normal degree of DNA repair synthesis after treatment with MNNG. When the clone-forming capacity was examined the XP cells exhibited (1) a higher increased sensitivity to the various carcinogenic N-oxides, (2) no reduction in the clone formation following 6NQO and (3) a sensitivity virtually comparable to that of normal cells after treatment with MNNG. The results suggest a link between extent of DNA damage, level of DNA repair and degree of sensitivity in human cells exposed to various chemical carcinogens and which induce DNA alterations that cannot be repaired by DNA repair synthesis." @default.
- W2000722792 created "2016-06-24" @default.
- W2000722792 creator A5034525554 @default.
- W2000722792 creator A5071160133 @default.
- W2000722792 creator A5075804151 @default.
- W2000722792 date "1973-01-01" @default.
- W2000722792 modified "2023-10-15" @default.
- W2000722792 title "Increased sensitivity of xeroderma pigmentosum cells to some chemical carcinogens and mutagens" @default.
- W2000722792 cites W1848310822 @default.
- W2000722792 cites W1972316649 @default.
- W2000722792 cites W1983825404 @default.
- W2000722792 cites W1984459901 @default.
- W2000722792 cites W1993455407 @default.
- W2000722792 cites W2001120370 @default.
- W2000722792 cites W2002442895 @default.
- W2000722792 cites W2005966750 @default.
- W2000722792 cites W2008221413 @default.
- W2000722792 cites W2023853176 @default.
- W2000722792 cites W2024112413 @default.
- W2000722792 cites W2035010827 @default.
- W2000722792 cites W2046683882 @default.
- W2000722792 cites W2064647083 @default.
- W2000722792 cites W2070680969 @default.
- W2000722792 cites W2077756686 @default.
- W2000722792 cites W2083533679 @default.
- W2000722792 cites W2089243324 @default.
- W2000722792 cites W2151227614 @default.
- W2000722792 cites W2166661146 @default.
- W2000722792 cites W2330333096 @default.
- W2000722792 cites W4239216521 @default.
- W2000722792 doi "https://doi.org/10.1016/0027-5107(73)90261-3" @default.
- W2000722792 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4682598" @default.
- W2000722792 hasPublicationYear "1973" @default.
- W2000722792 type Work @default.
- W2000722792 sameAs 2000722792 @default.
- W2000722792 citedByCount "108" @default.
- W2000722792 crossrefType "journal-article" @default.
- W2000722792 hasAuthorship W2000722792A5034525554 @default.
- W2000722792 hasAuthorship W2000722792A5071160133 @default.
- W2000722792 hasAuthorship W2000722792A5075804151 @default.
- W2000722792 hasConcept C104317684 @default.
- W2000722792 hasConcept C104451858 @default.
- W2000722792 hasConcept C114246631 @default.
- W2000722792 hasConcept C134935766 @default.
- W2000722792 hasConcept C143425029 @default.
- W2000722792 hasConcept C153911025 @default.
- W2000722792 hasConcept C185592680 @default.
- W2000722792 hasConcept C2776639595 @default.
- W2000722792 hasConcept C2778378917 @default.
- W2000722792 hasConcept C2779911484 @default.
- W2000722792 hasConcept C2780625556 @default.
- W2000722792 hasConcept C501734568 @default.
- W2000722792 hasConcept C552990157 @default.
- W2000722792 hasConcept C55493867 @default.
- W2000722792 hasConcept C555283112 @default.
- W2000722792 hasConcept C81089528 @default.
- W2000722792 hasConcept C86803240 @default.
- W2000722792 hasConceptScore W2000722792C104317684 @default.
- W2000722792 hasConceptScore W2000722792C104451858 @default.
- W2000722792 hasConceptScore W2000722792C114246631 @default.
- W2000722792 hasConceptScore W2000722792C134935766 @default.
- W2000722792 hasConceptScore W2000722792C143425029 @default.
- W2000722792 hasConceptScore W2000722792C153911025 @default.
- W2000722792 hasConceptScore W2000722792C185592680 @default.
- W2000722792 hasConceptScore W2000722792C2776639595 @default.
- W2000722792 hasConceptScore W2000722792C2778378917 @default.
- W2000722792 hasConceptScore W2000722792C2779911484 @default.
- W2000722792 hasConceptScore W2000722792C2780625556 @default.
- W2000722792 hasConceptScore W2000722792C501734568 @default.
- W2000722792 hasConceptScore W2000722792C552990157 @default.
- W2000722792 hasConceptScore W2000722792C55493867 @default.
- W2000722792 hasConceptScore W2000722792C555283112 @default.
- W2000722792 hasConceptScore W2000722792C81089528 @default.
- W2000722792 hasConceptScore W2000722792C86803240 @default.
- W2000722792 hasIssue "1" @default.
- W2000722792 hasLocation W20007227921 @default.
- W2000722792 hasLocation W20007227922 @default.
- W2000722792 hasOpenAccess W2000722792 @default.
- W2000722792 hasPrimaryLocation W20007227921 @default.
- W2000722792 hasRelatedWork W1558436911 @default.
- W2000722792 hasRelatedWork W2007771316 @default.
- W2000722792 hasRelatedWork W2013533973 @default.
- W2000722792 hasRelatedWork W2030561146 @default.
- W2000722792 hasRelatedWork W2031886171 @default.
- W2000722792 hasRelatedWork W2108192168 @default.
- W2000722792 hasRelatedWork W2113687378 @default.
- W2000722792 hasRelatedWork W2122020045 @default.
- W2000722792 hasRelatedWork W2960892660 @default.
- W2000722792 hasRelatedWork W3029089583 @default.
- W2000722792 hasVolume "17" @default.
- W2000722792 isParatext "false" @default.
- W2000722792 isRetracted "false" @default.
- W2000722792 magId "2000722792" @default.
- W2000722792 workType "article" @default.