FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000722876> ?p ?o ?g. }

• W2000722876 endingPage "4655" @default.
• W2000722876 startingPage "4644" @default.
• W2000722876 abstract "Interneuronal subtype diversity lies at the heart of the distinct molecular properties and synaptic connections that shape the formation of the neuronal circuits that are necessary for the complex spatial and temporal processing of sensory information. Here, we investigate the role of Irx6, a member of the Iroquois homeodomain transcription factor family, in regulating the development of retinal bipolar interneurons. Using a knock-in reporter approach, we show that, in the mouse retina, Irx6 is expressed in type 2 and 3a OFF bipolar interneurons and is required for the expression of cell type-specific markers in these cells, likely through direct transcriptional regulation. In Irx6 mutant mice, presumptive type 3a bipolar cells exhibit an expansion of their axonal projection domain to the entire OFF region of the inner plexiform layer, and adopt molecular features of both type 2 and 3a bipolar cells, highlighted by the ectopic upregulation of neurokinin 3 receptor (Nk3r) and Vsx1. These findings reveal Irx6 as a key regulator of type 3a bipolar cell identity that prevents these cells from adopting characteristic features of type 2 bipolar cells. Analysis of the Irx6;Vsx1 double null retina suggests that the terminal differentiation of type 2 bipolar cells is dependent on the combined expression of the transcription factors Irx6 and Vsx1, but also points to the existence of Irx6;Vsx1-independent mechanisms in regulating OFF bipolar subtype-specific gene expression. This work provides insight into the generation of neuronal subtypes by revealing a mechanism in which opposing, yet interdependent, transcription factors regulate subtype identity." @default.
• W2000722876 created "2016-06-24" @default.
• W2000722876 creator A5002495760 @default.
• W2000722876 creator A5002700487 @default.
• W2000722876 creator A5007993675 @default.
• W2000722876 creator A5020639669 @default.
• W2000722876 creator A5028887362 @default.
• W2000722876 creator A5039219524 @default.
• W2000722876 creator A5055400144 @default.
• W2000722876 creator A5078276847 @default.
• W2000722876 date "2012-12-15" @default.
• W2000722876 modified "2023-10-16" @default.
• W2000722876 title "Regulation of retinal interneuron subtype identity by the<i>Iroquois</i>homeobox gene<i>Irx6</i>" @default.
• W2000722876 cites W1572325353 @default.
• W2000722876 cites W1974421363 @default.
• W2000722876 cites W1975004385 @default.
• W2000722876 cites W1979675055 @default.
• W2000722876 cites W1988106249 @default.
• W2000722876 cites W1992681894 @default.
• W2000722876 cites W1994197368 @default.
• W2000722876 cites W1995043049 @default.
• W2000722876 cites W1996605851 @default.
• W2000722876 cites W2001472734 @default.
• W2000722876 cites W2006595434 @default.
• W2000722876 cites W2008813184 @default.
• W2000722876 cites W2018931249 @default.
• W2000722876 cites W2018936581 @default.
• W2000722876 cites W2025114629 @default.
• W2000722876 cites W2033522367 @default.
• W2000722876 cites W2034262791 @default.
• W2000722876 cites W2043241080 @default.
• W2000722876 cites W2044805332 @default.
• W2000722876 cites W2049271482 @default.
• W2000722876 cites W2049934726 @default.
• W2000722876 cites W2057250698 @default.
• W2000722876 cites W2060395602 @default.
• W2000722876 cites W2061441992 @default.
• W2000722876 cites W2063640158 @default.
• W2000722876 cites W2069186336 @default.
• W2000722876 cites W2069305303 @default.
• W2000722876 cites W2071869299 @default.
• W2000722876 cites W2078186919 @default.
• W2000722876 cites W2080152736 @default.
• W2000722876 cites W2086582835 @default.
• W2000722876 cites W2099616257 @default.
• W2000722876 cites W2100467126 @default.
• W2000722876 cites W2112567404 @default.
• W2000722876 cites W2124109473 @default.
• W2000722876 cites W2132246429 @default.
• W2000722876 cites W2137855254 @default.
• W2000722876 cites W2149519740 @default.
• W2000722876 cites W2150391323 @default.
• W2000722876 cites W2165309344 @default.
• W2000722876 cites W2167058119 @default.
• W2000722876 cites W4248042899 @default.
• W2000722876 doi "https://doi.org/10.1242/dev.081729" @default.
• W2000722876 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3509726" @default.
• W2000722876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23172916" @default.
• W2000722876 hasPublicationYear "2012" @default.
• W2000722876 type Work @default.
• W2000722876 sameAs 2000722876 @default.
• W2000722876 citedByCount "28" @default.
• W2000722876 countsByYear W20007228762013 @default.
• W2000722876 countsByYear W20007228762014 @default.
• W2000722876 countsByYear W20007228762015 @default.
• W2000722876 countsByYear W20007228762018 @default.
• W2000722876 countsByYear W20007228762019 @default.
• W2000722876 countsByYear W20007228762020 @default.
• W2000722876 countsByYear W20007228762021 @default.
• W2000722876 countsByYear W20007228762022 @default.
• W2000722876 countsByYear W20007228762023 @default.
• W2000722876 crossrefType "journal-article" @default.
• W2000722876 hasAuthorship W2000722876A5002495760 @default.
• W2000722876 hasAuthorship W2000722876A5002700487 @default.
• W2000722876 hasAuthorship W2000722876A5007993675 @default.
• W2000722876 hasAuthorship W2000722876A5020639669 @default.
• W2000722876 hasAuthorship W2000722876A5028887362 @default.
• W2000722876 hasAuthorship W2000722876A5039219524 @default.
• W2000722876 hasAuthorship W2000722876A5055400144 @default.
• W2000722876 hasAuthorship W2000722876A5078276847 @default.
• W2000722876 hasBestOaLocation W20007228761 @default.
• W2000722876 hasConcept C104317684 @default.
• W2000722876 hasConcept C121587040 @default.
• W2000722876 hasConcept C1491633281 @default.
• W2000722876 hasConcept C169760540 @default.
• W2000722876 hasConcept C17077164 @default.
• W2000722876 hasConcept C189014844 @default.
• W2000722876 hasConcept C27153228 @default.
• W2000722876 hasConcept C2779296341 @default.
• W2000722876 hasConcept C54355233 @default.
• W2000722876 hasConcept C86339819 @default.
• W2000722876 hasConcept C86803240 @default.
• W2000722876 hasConcept C95444343 @default.
• W2000722876 hasConcept C97037327 @default.
• W2000722876 hasConceptScore W2000722876C104317684 @default.
• W2000722876 hasConceptScore W2000722876C121587040 @default.
• W2000722876 hasConceptScore W2000722876C1491633281 @default.
• W2000722876 hasConceptScore W2000722876C169760540 @default.

• next