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- W2000723306 abstract "Bioavailability problems have been encountered for calcium fluoride as a fluoride source in the remineralization of dental enamel. Satisfactory performance of a prototype delivery system in vitro could only be achieved under conditions of small particle size (sub-micron) and high loading (5 mg) of calcium fluoride. The most likely causes of this particle size/load effect were investigated. Dynamic dialysis studies revealed that any increased intrinsic solubility for the sub-micron calcium fluoride would be too small to account for the greater efficacy of this material for remineralization. The technique also indicated that the surface area of calcium fluoride should not be a crucial factor influencing the fluoride release rate under normal solution conditions. Studies conducted under conditions simulating those used for in vitro remineralization, however, revealed a marked inhibition of calcium fluoride dissolution by other components of the remineralizing system. The particle size effect/load effect on bioavailability of calcium fluoride is interpreted as an indirect surface area dependence resulting from the formation of an inhibitory surface complex which involves both solution calcium and phosphate ions." @default.
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- W2000723306 date "1983-09-01" @default.
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- W2000723306 title "Mechanistic studies on the bioavailability of calcium fluoride for remineralization of dental enamel" @default.
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- W2000723306 doi "https://doi.org/10.1016/0378-5173(83)90054-6" @default.
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