FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000723562> ?p ?o ?g. }

• W2000723562 abstract "The Beclin 1-Vps34 complex, the core component of the class III phosphatidylinositol-3 kinase (PI3K-III), binds Atg14L or UVRAG to control different steps of autophagy. However, the mechanism underlying the control of PI3K-III activity remains elusive. Here we report the identification of NRBF2 as a component in the specific PI3K-III complex and a modulator of PI3K-III activity. Through its microtubule interaction and trafficking (MIT) domain, NRBF2 binds Atg14L directly and enhances Atg14L-linked Vps34 kinase activity and autophagy induction. NRBF2-deficient cells exhibit enhanced vulnerability to endoplasmic reticulum (ER) stress that is reversed by re-introducing exogenous NRBF2. NRBF2-deficient mice develop focal liver necrosis and ductular reaction, accompanied by impaired Atg14L-linked Vps34 activity and autophagy, although the mice show no increased mortality. Our data reveal a key role for NRBF2 in the assembly of the specific Atg14L-Beclin 1-Vps34-Vps15 complex for autophagy induction. Thus, NRBF2 modulates autophagy via regulation of PI3K-III and prevents ER stress-mediated cytotoxicity and liver injury. Autophagosome biogenesis depends on the lipid kinase Vps34 and its binding proteins Beclin 1 and Atg14L. Lu et al.identify nuclear receptor binding factor 2 (NRBF2) as a regulator of this complex, and show that loss of NRBF2 impairs autophagy, enhances cell vulnerability to endoplasmic reticulum stress and promotes necrosis in the liver." @default.
• W2000723562 created "2016-06-24" @default.
• W2000723562 creator A5021959959 @default.
• W2000723562 creator A5022761217 @default.
• W2000723562 creator A5025714852 @default.
• W2000723562 creator A5047683515 @default.
• W2000723562 creator A5048543554 @default.
• W2000723562 creator A5050344464 @default.
• W2000723562 creator A5070554662 @default.
• W2000723562 creator A5070758909 @default.
• W2000723562 creator A5071368345 @default.
• W2000723562 creator A5072058320 @default.
• W2000723562 creator A5075613389 @default.
• W2000723562 creator A5076560982 @default.
• W2000723562 date "2014-05-22" @default.
• W2000723562 modified "2023-10-12" @default.
• W2000723562 title "NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity" @default.
• W2000723562 cites W170520254 @default.
• W2000723562 cites W1780295430 @default.
• W2000723562 cites W1784425676 @default.
• W2000723562 cites W1975491594 @default.
• W2000723562 cites W1981817858 @default.
• W2000723562 cites W1982332255 @default.
• W2000723562 cites W1983831622 @default.
• W2000723562 cites W1992659717 @default.
• W2000723562 cites W2013131355 @default.
• W2000723562 cites W2014918593 @default.
• W2000723562 cites W2045373134 @default.
• W2000723562 cites W2049173806 @default.
• W2000723562 cites W2053350368 @default.
• W2000723562 cites W2056663185 @default.
• W2000723562 cites W2063761428 @default.
• W2000723562 cites W2064381459 @default.
• W2000723562 cites W2064746187 @default.
• W2000723562 cites W2066800765 @default.
• W2000723562 cites W2078004915 @default.
• W2000723562 cites W2092321143 @default.
• W2000723562 cites W2094149522 @default.
• W2000723562 cites W2096348285 @default.
• W2000723562 cites W2104558541 @default.
• W2000723562 cites W2106969933 @default.
• W2000723562 cites W2116836791 @default.
• W2000723562 cites W2119385480 @default.
• W2000723562 cites W2136994247 @default.
• W2000723562 cites W2143070952 @default.
• W2000723562 cites W2143238979 @default.
• W2000723562 cites W2144522321 @default.
• W2000723562 cites W2146887271 @default.
• W2000723562 cites W2151084479 @default.
• W2000723562 cites W2155175976 @default.
• W2000723562 cites W2161050915 @default.
• W2000723562 doi "https://doi.org/10.1038/ncomms4920" @default.
• W2000723562 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4376476" @default.
• W2000723562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24849286" @default.
• W2000723562 hasPublicationYear "2014" @default.
• W2000723562 type Work @default.
• W2000723562 sameAs 2000723562 @default.
• W2000723562 citedByCount "103" @default.
• W2000723562 countsByYear W20007235622014 @default.
• W2000723562 countsByYear W20007235622015 @default.
• W2000723562 countsByYear W20007235622016 @default.
• W2000723562 countsByYear W20007235622017 @default.
• W2000723562 countsByYear W20007235622018 @default.
• W2000723562 countsByYear W20007235622019 @default.
• W2000723562 countsByYear W20007235622020 @default.
• W2000723562 countsByYear W20007235622021 @default.
• W2000723562 countsByYear W20007235622022 @default.
• W2000723562 countsByYear W20007235622023 @default.
• W2000723562 crossrefType "journal-article" @default.
• W2000723562 hasAuthorship W2000723562A5021959959 @default.
• W2000723562 hasAuthorship W2000723562A5022761217 @default.
• W2000723562 hasAuthorship W2000723562A5025714852 @default.
• W2000723562 hasAuthorship W2000723562A5047683515 @default.
• W2000723562 hasAuthorship W2000723562A5048543554 @default.
• W2000723562 hasAuthorship W2000723562A5050344464 @default.
• W2000723562 hasAuthorship W2000723562A5070554662 @default.
• W2000723562 hasAuthorship W2000723562A5070758909 @default.
• W2000723562 hasAuthorship W2000723562A5071368345 @default.
• W2000723562 hasAuthorship W2000723562A5072058320 @default.
• W2000723562 hasAuthorship W2000723562A5075613389 @default.
• W2000723562 hasAuthorship W2000723562A5076560982 @default.
• W2000723562 hasBestOaLocation W20007235621 @default.
• W2000723562 hasConcept C104317684 @default.
• W2000723562 hasConcept C131934819 @default.
• W2000723562 hasConcept C158617107 @default.
• W2000723562 hasConcept C168296220 @default.
• W2000723562 hasConcept C184235292 @default.
• W2000723562 hasConcept C185592680 @default.
• W2000723562 hasConcept C190283241 @default.
• W2000723562 hasConcept C203522944 @default.
• W2000723562 hasConcept C2780610907 @default.
• W2000723562 hasConcept C55493867 @default.
• W2000723562 hasConcept C62478195 @default.
• W2000723562 hasConcept C86554907 @default.
• W2000723562 hasConcept C86803240 @default.
• W2000723562 hasConcept C95444343 @default.
• W2000723562 hasConceptScore W2000723562C104317684 @default.
• W2000723562 hasConceptScore W2000723562C131934819 @default.
• W2000723562 hasConceptScore W2000723562C158617107 @default.
• W2000723562 hasConceptScore W2000723562C168296220 @default.

• next