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• W2000723582 startingPage "247" @default.
• W2000723582 abstract "Intervertebral disc degeneration, which mimics disc aging but occurs at an accelerated rate, is considered to be related to neck or low back pain and disc herniation. Degenerated discs show breakdown of the extracellular matrix and thus fail to bear the daily loadings exerted on the spine. Rather than a passive process of wear and tear, disc degeneration is an aberrant, cell-mediated response to progressive structural failure due to aging and other environmental factors such as abnormal mechanical stress. With aging and degeneration, disc cells undergo substantially biologic changes, including alternation of cell type in the nucleus pulposus, increased cell density but decreased number of viable cells as a result of increased cell death and increased cell proliferation, increased cell senescence, and altered cell phenotype which is characterized by compromised capability of synthesizing correct matrix components and by enhanced catabolic metabolism. These changes are involved in the process of disc degeneration through the complicated interactions among them. To retard or reverse disc degeneration, the abnormal conditions of the decreased viable cell population and the altered cell phenotype should be corrected. As potential therapies for disc degeneration, intradiscal protein injection, gene transfer and cell implantation are being understudied in vivo. Suppression of excessive apoptosis and accelerated senescence of disc cells may be other choices for treating disc degeneration. When performing a biologic therapy in order to repair or regenerate the degenerated disc, nutrient and biomechanical factors should also be incorporated, because they are the major causes of the biologic changes experienced by disc cells. Moreover, a very early intervention is indicated by the finding that the onset of human disc degeneration occurs as early as by adolescence." @default.
• W2000723582 created "2016-06-24" @default.
• W2000723582 creator A5002200941 @default.
• W2000723582 creator A5059857556 @default.
• W2000723582 creator A5072131803 @default.
• W2000723582 creator A5073435344 @default.
• W2000723582 date "2007-10-01" @default.
• W2000723582 modified "2023-10-03" @default.
• W2000723582 title "The cell biology of intervertebral disc aging and degeneration" @default.
• W2000723582 cites W105394047 @default.
• W2000723582 cites W106776827 @default.
• W2000723582 cites W143623202 @default.
• W2000723582 cites W1453797714 @default.
• W2000723582 cites W1482343191 @default.
• W2000723582 cites W1505597474 @default.
• W2000723582 cites W1533564224 @default.
• W2000723582 cites W1841858344 @default.
• W2000723582 cites W1964178830 @default.
• W2000723582 cites W1964978092 @default.
• W2000723582 cites W1965024650 @default.
• W2000723582 cites W1965245788 @default.
• W2000723582 cites W1965282660 @default.
• W2000723582 cites W1966782529 @default.
• W2000723582 cites W1966973660 @default.
• W2000723582 cites W1968320346 @default.
• W2000723582 cites W1969094972 @default.
• W2000723582 cites W1971036564 @default.
• W2000723582 cites W1973847681 @default.
• W2000723582 cites W1978822037 @default.
• W2000723582 cites W1979233208 @default.
• W2000723582 cites W1981966474 @default.
• W2000723582 cites W1986207703 @default.
• W2000723582 cites W1986868734 @default.
• W2000723582 cites W1988250393 @default.
• W2000723582 cites W1989517472 @default.
• W2000723582 cites W1989731738 @default.
• W2000723582 cites W1989736422 @default.
• W2000723582 cites W1990730164 @default.
• W2000723582 cites W1991192053 @default.
• W2000723582 cites W1991606527 @default.
• W2000723582 cites W1993946232 @default.
• W2000723582 cites W1994654873 @default.
• W2000723582 cites W1994834259 @default.
• W2000723582 cites W1995650257 @default.
• W2000723582 cites W1997420170 @default.
• W2000723582 cites W1999138373 @default.
• W2000723582 cites W2000287184 @default.
• W2000723582 cites W2001436617 @default.
• W2000723582 cites W2005247492 @default.
• W2000723582 cites W2005298420 @default.
• W2000723582 cites W2005958284 @default.
• W2000723582 cites W2007413067 @default.
• W2000723582 cites W2008353525 @default.
• W2000723582 cites W2008441701 @default.
• W2000723582 cites W2011378171 @default.
• W2000723582 cites W2011961608 @default.
• W2000723582 cites W2012276832 @default.
• W2000723582 cites W2012650711 @default.
• W2000723582 cites W2018869849 @default.
• W2000723582 cites W2019246150 @default.
• W2000723582 cites W2020381981 @default.
• W2000723582 cites W2021449823 @default.
• W2000723582 cites W2024585159 @default.
• W2000723582 cites W2025853381 @default.
• W2000723582 cites W2026038471 @default.
• W2000723582 cites W2028651742 @default.
• W2000723582 cites W2034271959 @default.
• W2000723582 cites W2034614591 @default.
• W2000723582 cites W2035554074 @default.
• W2000723582 cites W2036264639 @default.
• W2000723582 cites W2036763406 @default.
• W2000723582 cites W2037380947 @default.
• W2000723582 cites W2037767922 @default.
• W2000723582 cites W2037998434 @default.
• W2000723582 cites W2041547750 @default.
• W2000723582 cites W2041689053 @default.
• W2000723582 cites W2042190431 @default.
• W2000723582 cites W2042774958 @default.
• W2000723582 cites W2046200848 @default.
• W2000723582 cites W2047330128 @default.
• W2000723582 cites W2051970129 @default.
• W2000723582 cites W2053173623 @default.
• W2000723582 cites W2055011209 @default.
• W2000723582 cites W2055371580 @default.
• W2000723582 cites W2057259147 @default.
• W2000723582 cites W2059123383 @default.
• W2000723582 cites W2060600598 @default.
• W2000723582 cites W2060861339 @default.
• W2000723582 cites W2061401525 @default.
• W2000723582 cites W2061456864 @default.
• W2000723582 cites W2062712136 @default.
• W2000723582 cites W2063590231 @default.
• W2000723582 cites W2065246790 @default.
• W2000723582 cites W2065580273 @default.
• W2000723582 cites W2066826378 @default.
• W2000723582 cites W2067140883 @default.
• W2000723582 cites W2067364761 @default.
• W2000723582 cites W2067682644 @default.

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