Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000723894> ?p ?o ?g. }
- W2000723894 endingPage "1189" @default.
- W2000723894 startingPage "1181" @default.
- W2000723894 abstract "Several studies have shown an increase in beta cell mass during pregnancy. Somatolactogenic hormones are known to stimulate the proliferation of existing beta cells in rodents whereas the mechanism in humans is still unclear. We hypothesize that in addition to somatolactogenic hormones there are other circulating factors involved in beta cell adaptation to pregnancy. This study aimed at screening for potential pregnancy-associated circulating beta cell growth factors.Serum samples from nonpregnant and pregnant women.The effect of serum from pregnant women on the proliferation of rat beta cells was studied using [3H]thymidine incorporation and 5-ethynyl-2'-deoxyuridine proliferation assays. In addition, serum from pregnant and nonpregnant women was fractionated by gel filtration and high performance liquid chromatography. The fractionated serum was screened for mitogenic activity in INS-1E cells. Proteins and peptides in mitogenic active serum fractions were identified by amino acid sequencing and mass spectrometry.Presence of circulating beta cell proliferating factors.Late gestational pregnancy serum significantly increased proliferation of rat beta cells compared with early pregnancy and nonpregnancy. The mitogenic active serum fractions contained proteins and peptides derived from kininogen-1, fibrinogen-α, α1-antitrypsin, apolipoprotein-A1, placental lactogen, angiotensinogen and serum albumin.Pregnancy serum is able to stimulate proliferation of rat beta cells. We have identified several circulating factors that may contribute to beta cell adaptation to pregnancy. Further studies are needed to elucidate their possible role in glucose homeostasis in the mother and her offspring." @default.
- W2000723894 created "2016-06-24" @default.
- W2000723894 creator A5004190514 @default.
- W2000723894 creator A5005032064 @default.
- W2000723894 creator A5009299658 @default.
- W2000723894 creator A5012248965 @default.
- W2000723894 creator A5024421022 @default.
- W2000723894 creator A5025418429 @default.
- W2000723894 creator A5030190144 @default.
- W2000723894 creator A5030965826 @default.
- W2000723894 creator A5041121125 @default.
- W2000723894 creator A5043413733 @default.
- W2000723894 creator A5080195409 @default.
- W2000723894 date "2014-10-16" @default.
- W2000723894 modified "2023-10-17" @default.
- W2000723894 title "Implications for the offspring of circulating factors involved in beta cell adaptation in pregnancy" @default.
- W2000723894 cites W1605392416 @default.
- W2000723894 cites W1947340963 @default.
- W2000723894 cites W1971374614 @default.
- W2000723894 cites W1982824346 @default.
- W2000723894 cites W1988702698 @default.
- W2000723894 cites W1993046413 @default.
- W2000723894 cites W2003522581 @default.
- W2000723894 cites W2007817771 @default.
- W2000723894 cites W2011220884 @default.
- W2000723894 cites W2012135569 @default.
- W2000723894 cites W2017572901 @default.
- W2000723894 cites W2032268532 @default.
- W2000723894 cites W2035940741 @default.
- W2000723894 cites W2036800308 @default.
- W2000723894 cites W2048349743 @default.
- W2000723894 cites W2051567027 @default.
- W2000723894 cites W2054489926 @default.
- W2000723894 cites W2055201358 @default.
- W2000723894 cites W2057598447 @default.
- W2000723894 cites W2059724567 @default.
- W2000723894 cites W2076000587 @default.
- W2000723894 cites W2076035297 @default.
- W2000723894 cites W2079007791 @default.
- W2000723894 cites W2079577144 @default.
- W2000723894 cites W2088832307 @default.
- W2000723894 cites W2098789212 @default.
- W2000723894 cites W2104584321 @default.
- W2000723894 cites W2105598098 @default.
- W2000723894 cites W2114643862 @default.
- W2000723894 cites W2141160128 @default.
- W2000723894 cites W2148486284 @default.
- W2000723894 cites W2161783089 @default.
- W2000723894 cites W2164832587 @default.
- W2000723894 cites W2165234914 @default.
- W2000723894 cites W2168932510 @default.
- W2000723894 cites W2170080035 @default.
- W2000723894 cites W2317184793 @default.
- W2000723894 cites W4230231446 @default.
- W2000723894 doi "https://doi.org/10.1111/aogs.12505" @default.
- W2000723894 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25223212" @default.
- W2000723894 hasPublicationYear "2014" @default.
- W2000723894 type Work @default.
- W2000723894 sameAs 2000723894 @default.
- W2000723894 citedByCount "7" @default.
- W2000723894 countsByYear W20007238942014 @default.
- W2000723894 countsByYear W20007238942016 @default.
- W2000723894 countsByYear W20007238942020 @default.
- W2000723894 countsByYear W20007238942022 @default.
- W2000723894 crossrefType "journal-article" @default.
- W2000723894 hasAuthorship W2000723894A5004190514 @default.
- W2000723894 hasAuthorship W2000723894A5005032064 @default.
- W2000723894 hasAuthorship W2000723894A5009299658 @default.
- W2000723894 hasAuthorship W2000723894A5012248965 @default.
- W2000723894 hasAuthorship W2000723894A5024421022 @default.
- W2000723894 hasAuthorship W2000723894A5025418429 @default.
- W2000723894 hasAuthorship W2000723894A5030190144 @default.
- W2000723894 hasAuthorship W2000723894A5030965826 @default.
- W2000723894 hasAuthorship W2000723894A5041121125 @default.
- W2000723894 hasAuthorship W2000723894A5043413733 @default.
- W2000723894 hasAuthorship W2000723894A5080195409 @default.
- W2000723894 hasBestOaLocation W20007238941 @default.
- W2000723894 hasConcept C126322002 @default.
- W2000723894 hasConcept C134018914 @default.
- W2000723894 hasConcept C172680121 @default.
- W2000723894 hasConcept C2776953305 @default.
- W2000723894 hasConcept C2777064457 @default.
- W2000723894 hasConcept C2777675195 @default.
- W2000723894 hasConcept C2779234561 @default.
- W2000723894 hasConcept C54355233 @default.
- W2000723894 hasConcept C55493867 @default.
- W2000723894 hasConcept C62112901 @default.
- W2000723894 hasConcept C71924100 @default.
- W2000723894 hasConcept C86803240 @default.
- W2000723894 hasConceptScore W2000723894C126322002 @default.
- W2000723894 hasConceptScore W2000723894C134018914 @default.
- W2000723894 hasConceptScore W2000723894C172680121 @default.
- W2000723894 hasConceptScore W2000723894C2776953305 @default.
- W2000723894 hasConceptScore W2000723894C2777064457 @default.
- W2000723894 hasConceptScore W2000723894C2777675195 @default.
- W2000723894 hasConceptScore W2000723894C2779234561 @default.
- W2000723894 hasConceptScore W2000723894C54355233 @default.
- W2000723894 hasConceptScore W2000723894C55493867 @default.