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- W2000724279 abstract "Abstract The present study aimed to characterize the high cholesterol diet-induced hyperlipoproteinemia developed in thyroidectomized hypothyroid rats, in such animals the activities of hepatic triglyceride lipase having been shown to be decreased. Feeding a diet containing 1% cholesterol to normal control rats resulted in hypercholesterolemia characterized by increases of VLDL, IDL and LDL. The feeding of cholesterol to hypothyroid rats produced a marked accentuation of hypercholesterolemia characterized by a large increase in IDL with a lesser increase in LDL. The IDL contained an increased amount of apo E. The VLDL of cholesterol-fed hypothyroid rats contained β-VLDL. These findings indicate a marked accumulation of remnant lipoproteins in the plasma of cholesterol-fed hypothyroid rats. Putting this and our previous findings together, we suggest that such an accumulation may be caused by impaired removal by the liver of remnant lipoproteins due to the decreased activities of hepatic triglyceride lipase." @default.
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- W2000724279 date "1983-02-01" @default.
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- W2000724279 title "Accumulation of intermediate density lipoprotein in the plasma of cholesterol-fed hypothyroid rats" @default.
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- W2000724279 doi "https://doi.org/10.1016/0026-0495(83)90220-2" @default.
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