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• W2000726054 abstract "Small ubiquitin-like modifier (SUMO)2/3 but not SUMO1 conjugation is activated after transient cerebral ischemia. To investigate its function, we blocked neuronal SUMO2/3 translation through lentiviral microRNA delivery in primary cortical neurons. Viability was unaffected by SUMO2/3 silencing unless neurons were stressed by transient oxygen–glucose deprivation (OGD). Both 15 and 45 minutes of OGD were tolerated by control microRNA-expressing neurons but damaged >60% of neurons expressing SUMO2/3 microRNA. Damaging OGD (75 minutes) increased neuronal loss to 54% (control microRNA) and to 99% (SUMO2/3 microRNA). This suggests that activation of SUMO2/3 conjugation is an endogenous neuroprotective stress response." @default.
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• W2000726054 date "2011-08-24" @default.
• W2000726054 modified "2023-10-17" @default.
• W2000726054 title "SUMO2/3 Conjugation is an Endogenous Neuroprotective Mechanism" @default.
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• W2000726054 doi "https://doi.org/10.1038/jcbfm.2011.112" @default.
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