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• W2000726081 abstract "A variety of estrogenic compounds exist in the environment, both natural (phyto- and fungal estrogens) and synthetic (e.g. pesticides, industrial contaminants). Recent studies have suggested that a number of reproductive abnormalities in wildlife and human populations could be due to embryonic exposure to ecoestrogens. These abnormalities include modifications in gonadal structure and functioning, abnormalities in genital morphology and size, depressed plasma sex steroid concentrations and various reproductive organ cancers. We review briefly some of these studies as well as those providing data that identify various ecoestrogens. The data to date suggest that a wide variety of compounds can interact with the estrogen receptor and can stimulate estrogen-associated responses. Compared with 17β-estradiol, ecoestrogens have a weak binding affinity for the estrogen receptor and thus have been described as weak estrogens. However, we hypothesize that the estrogenic action of these compounds is augmented by their bioavailability and persistence. Initial testing demonstrates that some ecoestrogens show relatively little affinity for plasma binding proteins; thus, the majority of the estrogenic compound in the plasma is available for translocation into the cell. Likewise, many synthetic ecoestrogens appear to persist for months or years, stored in body fat. Future research needs to examine in more detail the relative roles of receptor affinity, cellular availability, and nuclear persistence in determining the estrogenicity of ecoestrogens. Only then, will we begin to understand the true role of these compounds in ecosystems." @default.
• W2000726081 created "2016-06-24" @default.
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• W2000726081 date "1996-04-01" @default.
• W2000726081 modified "2023-10-14" @default.
• W2000726081 title "Ecoestrogens and embryos—Is there a scientific basis for concern?" @default.
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• W2000726081 doi "https://doi.org/10.1016/0378-4320(96)01514-x" @default.
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