FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000726417> ?p ?o ?g. }

• W2000726417 endingPage "140" @default.
• W2000726417 startingPage "126" @default.
• W2000726417 abstract "Double in situ hybridization with mercurated and biotinylated chromosome specific DNA probes in combination with digital image analysis provides a new approach to compare the distribution of homologous and nonhomologous chromosome targets within individual interphase nuclei. Here we have used two DNA probes representing tandemly repeated sequences specific for the constitutive heterochromatin of the human chromosomes 1 and 15, respectively, and studied the relative arrangements of these chromosome targets in interphase nuclei of human lymphocytes, amniotic fluid cells, and fibroblasts, cultivated in vitro. We have developed a 2D-image analysis approach which allows the rapid evaluation of large numbers of interphase nuclei. Models to test for a random versus nonrandom distribution of chromosome segments are discussed taking into account the three-dimensional origin of the evaluated 2D-distribution. In all three human diploid cell types the measurements of target-target and target-center distances in the 2D-nuclear image revealed that the labeled segments of the two chromosomes 15 were distributed both significantly closer to each other and closer to the center of the nuclear image than the labeled chromosome 1 segments. This result can be explained by the association of nucleolus organizer regions on the short arm of chromosome 15 with nucleoli located more centrally in these nuclei and does not provide evidence for a homologous association per se. In contrast, evaluation of the interphase positioning of the two chromosome 1 segments fits the random expectation in amniotic fluid and fibroblast cells, while in experiments using lymphocytes a slight excess of larger distances between these homologous targets was occasionally observed. 2D-distances between the labeled chromosome 1 and 15 segments showed a large variability in their relative positioning. In conclusion our data do not support the idea of a strict and permanent association of these homologous and nonhomologous targets in the cell types studied so far." @default.
• W2000726417 created "2016-06-24" @default.
• W2000726417 creator A5006143467 @default.
• W2000726417 creator A5007351210 @default.
• W2000726417 creator A5015972472 @default.
• W2000726417 creator A5023822153 @default.
• W2000726417 creator A5035062788 @default.
• W2000726417 creator A5055256976 @default.
• W2000726417 creator A5058586071 @default.
• W2000726417 creator A5064624857 @default.
• W2000726417 creator A5073969481 @default.
• W2000726417 creator A5083290106 @default.
• W2000726417 date "1989-03-01" @default.
• W2000726417 modified "2023-09-24" @default.
• W2000726417 title "Double in situ hybridization in combination with digital image analysis: A new approach to study interphase chromosome topography" @default.
• W2000726417 cites W1973173192 @default.
• W2000726417 cites W1988493033 @default.
• W2000726417 cites W2002055583 @default.
• W2000726417 cites W2007181379 @default.
• W2000726417 cites W2008544773 @default.
• W2000726417 cites W2014214737 @default.
• W2000726417 cites W2018935896 @default.
• W2000726417 cites W2019241418 @default.
• W2000726417 cites W2021982857 @default.
• W2000726417 cites W2028626193 @default.
• W2000726417 cites W2029316747 @default.
• W2000726417 cites W2030638925 @default.
• W2000726417 cites W2035801536 @default.
• W2000726417 cites W2038932806 @default.
• W2000726417 cites W2042562742 @default.
• W2000726417 cites W2047135405 @default.
• W2000726417 cites W2048698092 @default.
• W2000726417 cites W2051382117 @default.
• W2000726417 cites W2052941603 @default.
• W2000726417 cites W2056793770 @default.
• W2000726417 cites W2058316914 @default.
• W2000726417 cites W2063516083 @default.
• W2000726417 cites W2073068828 @default.
• W2000726417 cites W2080432637 @default.
• W2000726417 cites W2087217739 @default.
• W2000726417 cites W2093721295 @default.
• W2000726417 cites W2099489108 @default.
• W2000726417 cites W2113645806 @default.
• W2000726417 cites W2138878968 @default.
• W2000726417 cites W2168950642 @default.
• W2000726417 cites W2170419840 @default.
• W2000726417 doi "https://doi.org/10.1016/0014-4827(89)90188-2" @default.
• W2000726417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2917599" @default.
• W2000726417 hasPublicationYear "1989" @default.
• W2000726417 type Work @default.
• W2000726417 sameAs 2000726417 @default.
• W2000726417 citedByCount "80" @default.
• W2000726417 countsByYear W20007264172022 @default.
• W2000726417 countsByYear W20007264172023 @default.
• W2000726417 crossrefType "journal-article" @default.
• W2000726417 hasAuthorship W2000726417A5006143467 @default.
• W2000726417 hasAuthorship W2000726417A5007351210 @default.
• W2000726417 hasAuthorship W2000726417A5015972472 @default.
• W2000726417 hasAuthorship W2000726417A5023822153 @default.
• W2000726417 hasAuthorship W2000726417A5035062788 @default.
• W2000726417 hasAuthorship W2000726417A5055256976 @default.
• W2000726417 hasAuthorship W2000726417A5058586071 @default.
• W2000726417 hasAuthorship W2000726417A5064624857 @default.
• W2000726417 hasAuthorship W2000726417A5073969481 @default.
• W2000726417 hasAuthorship W2000726417A5083290106 @default.
• W2000726417 hasBestOaLocation W20007264172 @default.
• W2000726417 hasConcept C103435993 @default.
• W2000726417 hasConcept C104317684 @default.
• W2000726417 hasConcept C153911025 @default.
• W2000726417 hasConcept C183873130 @default.
• W2000726417 hasConcept C190062978 @default.
• W2000726417 hasConcept C29452124 @default.
• W2000726417 hasConcept C30481170 @default.
• W2000726417 hasConcept C54355233 @default.
• W2000726417 hasConcept C64894306 @default.
• W2000726417 hasConcept C72391661 @default.
• W2000726417 hasConcept C86803240 @default.
• W2000726417 hasConceptScore W2000726417C103435993 @default.
• W2000726417 hasConceptScore W2000726417C104317684 @default.
• W2000726417 hasConceptScore W2000726417C153911025 @default.
• W2000726417 hasConceptScore W2000726417C183873130 @default.
• W2000726417 hasConceptScore W2000726417C190062978 @default.
• W2000726417 hasConceptScore W2000726417C29452124 @default.
• W2000726417 hasConceptScore W2000726417C30481170 @default.
• W2000726417 hasConceptScore W2000726417C54355233 @default.
• W2000726417 hasConceptScore W2000726417C64894306 @default.
• W2000726417 hasConceptScore W2000726417C72391661 @default.
• W2000726417 hasConceptScore W2000726417C86803240 @default.
• W2000726417 hasIssue "1" @default.
• W2000726417 hasLocation W20007264171 @default.
• W2000726417 hasLocation W20007264172 @default.
• W2000726417 hasLocation W20007264173 @default.
• W2000726417 hasOpenAccess W2000726417 @default.
• W2000726417 hasPrimaryLocation W20007264171 @default.
• W2000726417 hasRelatedWork W1969681539 @default.
• W2000726417 hasRelatedWork W1988493033 @default.
• W2000726417 hasRelatedWork W1988535249 @default.
• W2000726417 hasRelatedWork W2000726417 @default.

• next