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• W2000727431 abstract "Using several reactions that include homologations and asymmetric epoxidations as well as Ugi and Huisgen couplings, we generated a small focused library of new derivatives from the labdane-type diterpene grindelic acid. These compounds were evaluated as cytotoxic agents against a panel of five human solid tumor cell lines (HBL-100, HeLa, SW1573, T-47D, and WiDr). The presence of the diamide functionalizations enhanced the cytotoxic effect. N-Benzyl-N-(1-(benzylamino)-2-methyl-1-oxopropan-2-yl)grindelicamide, proved to be the most active product in all cell lines tested, with values of 0.95 (±0.38) μM against HBL-100 cells." @default.
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• W2000727431 date "2013-09-01" @default.
• W2000727431 modified "2023-10-06" @default.
• W2000727431 title "Derivatives of grindelic acid: From a non-active natural diterpene to synthetic antitumor derivatives" @default.
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• W2000727431 doi "https://doi.org/10.1016/j.ejmech.2013.06.013" @default.
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