FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000728228> ?p ?o ?g. }

• W2000728228 endingPage "2488" @default.
• W2000728228 startingPage "2476" @default.
• W2000728228 abstract "It has been shown that anxiety and stress responses are modulated by substance P (SP) released within the amygdala. However, there is an important gap in our knowledge concerning the mechanisms regulating extracellular SP in this brain region. To study a possible self-regulating role of SP, we used a selective neurokinin-1 (NK1) receptor antagonist to investigate whether blockade of NK1 receptors results in altered basal and/or stress-evoked SP release in the medial amygdala (MeA), a critical brain area for a functional involvement of SP transmission in enhanced anxiety responses induced by stressor exposure. In vitro binding and functional receptor assays revealed that L-822429 represents a potent and selective rat NK1 receptor antagonist. Intra-amygdaloid administration of L-822429 via inverse microdialysis enhanced basal, but attenuated swim stress-induced SP release, while the low-affinity enantiomer of L-822429 had no effect. Using light and electron microscopy, synaptic contacts between SP-containing fibres and dendrites expressing NK1 receptors was demonstrated in the medial amygdala. Our findings suggest self-regulatory capacity of SP-mediated neurotransmission that differs in the effect on basal and stress-induced release of SP. Under basal conditions endogenous SP can serve as a signal that tonically inhibits its own release via a NK1 receptor-mediated negative feedback action, while under stress conditions SP release is further facilitated by activation of NK1 receptors, likely leading to high local levels of SP and activation of receptors to which SP binds with lower affinity." @default.
• W2000728228 created "2016-06-24" @default.
• W2000728228 creator A5005827647 @default.
• W2000728228 creator A5017587778 @default.
• W2000728228 creator A5022198549 @default.
• W2000728228 creator A5029656681 @default.
• W2000728228 creator A5040398033 @default.
• W2000728228 creator A5041241512 @default.
• W2000728228 creator A5054178855 @default.
• W2000728228 creator A5056488783 @default.
• W2000728228 creator A5071677368 @default.
• W2000728228 creator A5073099487 @default.
• W2000728228 date "2008-09-01" @default.
• W2000728228 modified "2023-10-17" @default.
• W2000728228 title "Modulation of basal and stress‐induced amygdaloid substance P release by the potent and selective NK1 receptor antagonist L‐822429" @default.
• W2000728228 cites W1967318820 @default.
• W2000728228 cites W1971047145 @default.
• W2000728228 cites W1971288730 @default.
• W2000728228 cites W1972480530 @default.
• W2000728228 cites W1977098106 @default.
• W2000728228 cites W1977526257 @default.
• W2000728228 cites W1978080244 @default.
• W2000728228 cites W1978713404 @default.
• W2000728228 cites W1979347499 @default.
• W2000728228 cites W1979446291 @default.
• W2000728228 cites W1980839404 @default.
• W2000728228 cites W1985219627 @default.
• W2000728228 cites W1993230172 @default.
• W2000728228 cites W1995344815 @default.
• W2000728228 cites W1995761892 @default.
• W2000728228 cites W1996433434 @default.
• W2000728228 cites W1997571015 @default.
• W2000728228 cites W1998121237 @default.
• W2000728228 cites W2000811564 @default.
• W2000728228 cites W2001989148 @default.
• W2000728228 cites W2003847276 @default.
• W2000728228 cites W2004251390 @default.
• W2000728228 cites W2005733450 @default.
• W2000728228 cites W2006750357 @default.
• W2000728228 cites W2008904303 @default.
• W2000728228 cites W2010196759 @default.
• W2000728228 cites W2010813263 @default.
• W2000728228 cites W2014917362 @default.
• W2000728228 cites W2018048919 @default.
• W2000728228 cites W2018843055 @default.
• W2000728228 cites W2023800668 @default.
• W2000728228 cites W2024741077 @default.
• W2000728228 cites W2025677698 @default.
• W2000728228 cites W2026483099 @default.
• W2000728228 cites W2027972575 @default.
• W2000728228 cites W2030025448 @default.
• W2000728228 cites W2032104699 @default.
• W2000728228 cites W2037048890 @default.
• W2000728228 cites W2037331404 @default.
• W2000728228 cites W2038478529 @default.
• W2000728228 cites W2041889311 @default.
• W2000728228 cites W2041930616 @default.
• W2000728228 cites W2044976309 @default.
• W2000728228 cites W2045030807 @default.
• W2000728228 cites W2045595943 @default.
• W2000728228 cites W2047470848 @default.
• W2000728228 cites W2052215218 @default.
• W2000728228 cites W2052772958 @default.
• W2000728228 cites W2054112672 @default.
• W2000728228 cites W2055505440 @default.
• W2000728228 cites W2060298854 @default.
• W2000728228 cites W2060840182 @default.
• W2000728228 cites W2062054732 @default.
• W2000728228 cites W2062213415 @default.
• W2000728228 cites W2062254178 @default.
• W2000728228 cites W2063360806 @default.
• W2000728228 cites W2064918933 @default.
• W2000728228 cites W2066099032 @default.
• W2000728228 cites W2069331924 @default.
• W2000728228 cites W2072553414 @default.
• W2000728228 cites W2073570537 @default.
• W2000728228 cites W2079311820 @default.
• W2000728228 cites W2081292327 @default.
• W2000728228 cites W2081732610 @default.
• W2000728228 cites W2084988952 @default.
• W2000728228 cites W2085032279 @default.
• W2000728228 cites W2086779277 @default.
• W2000728228 cites W2088632365 @default.
• W2000728228 cites W2088781238 @default.
• W2000728228 cites W2088786617 @default.
• W2000728228 cites W2089946826 @default.
• W2000728228 cites W2090278531 @default.
• W2000728228 cites W2091497325 @default.
• W2000728228 cites W2092183051 @default.
• W2000728228 cites W2093225726 @default.
• W2000728228 cites W2094681881 @default.
• W2000728228 cites W2113632518 @default.
• W2000728228 cites W2114842312 @default.
• W2000728228 cites W2119182443 @default.
• W2000728228 cites W2127828417 @default.
• W2000728228 cites W2129851648 @default.
• W2000728228 cites W2134797633 @default.
• W2000728228 cites W2139465206 @default.

• next