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- W2000728733 abstract "When unilateral, bipolar, amygdaloid stimulation is applied daily to rats and other animals, there is a gradual development of epileptic activity. The purpose of the present investigation was to study the effects of current intensity on this “kindling≓ process in the rat. Accordingly, two groups of rats were stimulated daily, one at a level just above the after discharge (AD) threshold (low-intensity group) and the other (high-intensity group) at a much higher level (500 μA). Although neither level of stimulation ever failed to elicit an AD over the 60 daily stimulations, there were considerable differences between the two groups in the course of epileptogenesis. The high-intensity current produced seizures which were initially (for the first 20 stimulations) longer both in terms of ADs and motor seizures (MSs) and which were consistently characterized by a more severe pattern of MS activity. Moreover, kindling progressed more rapidly in the high-intensity group with fewer stimulations required to produce the first “complete≓ MS, and the high-intensity stimulation produced much less day-to-day variation in epileptic activity once full seizures had developed." @default.
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- W2000728733 date "1974-05-01" @default.
- W2000728733 modified "2023-09-27" @default.
- W2000728733 title "Effects of current intensity on kindled motor seizure actitivy in rats" @default.
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- W2000728733 doi "https://doi.org/10.1016/s0091-6773(74)90184-9" @default.
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