FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000728814> ?p ?o ?g. }

• W2000728814 endingPage "170" @default.
• W2000728814 startingPage "163" @default.
• W2000728814 abstract "Novel dual‐functional PEI‐poly(γ‐cholesterol‐ l ‐glutamate) (PEI‐PCHLG) copolymers are developed for the first time. A series of PEI‐PCHLG (PEI‐1, PEI‐2, PEI‐3, and PEI‐4) with various PEI percentages and molecular weights are successfully synthesized, among which the poor organic solvent solubility of PEI‐1 precludes its further application. The other three copolymers can spontaneously self‐assemble into micelles; the critical micelle concentration (CMC) values are 0.66, 1.3, and 0.95 μmol L −1 , respectively. PEI‐2 and PEI‐4, with lower CMC, are worth being further developed as promising drug carriers because of their resistance to dilution in circulation after systemic administration. However, PEI‐4 can form smaller‐sized micelles than PEI‐2 and has similar in vitro cytotoxicity to PEI. Thus, PEI‐4 is further investigated. PEI‐4 micelles can not only incorporate docetaxel (DTX) with high encapsulation efficiency (91.0%) and drug loading (4.3%), but also load pDNA efficiently at a ratio of 8:1 (w/w). DTX‐loaded PEI‐4 micelles (DTX‐PEI‐4) can also carry genes with the same gene‐binding capacity as PEI‐4 micelles. The above three micelles (DTX‐PEI‐4, pDNA‐PEI‐4, and pDNA/DTX‐PEI‐4) are sub‐micrometer‐sized and spherical. The results indicate that PEI‐4 containing 28.9% PEI, one of the PEI‐PCHLG copoly­mers, is a potential carrier for gene delivery, drug delivery, or even drug/gene co‐delivery. image" @default.
• W2000728814 created "2016-06-24" @default.
• W2000728814 creator A5001838036 @default.
• W2000728814 creator A5010905234 @default.
• W2000728814 creator A5016029838 @default.
• W2000728814 creator A5022454880 @default.
• W2000728814 creator A5027096338 @default.
• W2000728814 creator A5033378462 @default.
• W2000728814 creator A5040059979 @default.
• W2000728814 creator A5047113062 @default.
• W2000728814 creator A5053960813 @default.
• W2000728814 creator A5075169308 @default.
• W2000728814 creator A5076381011 @default.
• W2000728814 date "2013-11-24" @default.
• W2000728814 modified "2023-10-16" @default.
• W2000728814 title "Dual-Functional PEI-Poly(γ-Cholesterol-<scp>l</scp> -Glutamate) Copolymer for Drug/Gene Co-delivery" @default.
• W2000728814 cites W1973458116 @default.
• W2000728814 cites W1983718760 @default.
• W2000728814 cites W1986566804 @default.
• W2000728814 cites W1992736089 @default.
• W2000728814 cites W1994192533 @default.
• W2000728814 cites W1997306106 @default.
• W2000728814 cites W2005908381 @default.
• W2000728814 cites W2008171455 @default.
• W2000728814 cites W2010655741 @default.
• W2000728814 cites W2011147896 @default.
• W2000728814 cites W2012809310 @default.
• W2000728814 cites W2013311947 @default.
• W2000728814 cites W2014693615 @default.
• W2000728814 cites W2019853172 @default.
• W2000728814 cites W2021202934 @default.
• W2000728814 cites W2037685491 @default.
• W2000728814 cites W2039577598 @default.
• W2000728814 cites W2058699293 @default.
• W2000728814 cites W2066567696 @default.
• W2000728814 cites W2087524587 @default.
• W2000728814 cites W2092000957 @default.
• W2000728814 cites W2095507086 @default.
• W2000728814 cites W2104451045 @default.
• W2000728814 cites W2115507942 @default.
• W2000728814 cites W2127644957 @default.
• W2000728814 cites W2127667644 @default.
• W2000728814 cites W2166042379 @default.
• W2000728814 cites W2166217368 @default.
• W2000728814 cites W2317537890 @default.
• W2000728814 doi "https://doi.org/10.1002/macp.201300551" @default.
• W2000728814 hasPublicationYear "2013" @default.
• W2000728814 type Work @default.
• W2000728814 sameAs 2000728814 @default.
• W2000728814 citedByCount "10" @default.
• W2000728814 countsByYear W20007288142015 @default.
• W2000728814 countsByYear W20007288142016 @default.
• W2000728814 countsByYear W20007288142017 @default.
• W2000728814 countsByYear W20007288142022 @default.
• W2000728814 crossrefType "journal-article" @default.
• W2000728814 hasAuthorship W2000728814A5001838036 @default.
• W2000728814 hasAuthorship W2000728814A5010905234 @default.
• W2000728814 hasAuthorship W2000728814A5016029838 @default.
• W2000728814 hasAuthorship W2000728814A5022454880 @default.
• W2000728814 hasAuthorship W2000728814A5027096338 @default.
• W2000728814 hasAuthorship W2000728814A5033378462 @default.
• W2000728814 hasAuthorship W2000728814A5040059979 @default.
• W2000728814 hasAuthorship W2000728814A5047113062 @default.
• W2000728814 hasAuthorship W2000728814A5053960813 @default.
• W2000728814 hasAuthorship W2000728814A5075169308 @default.
• W2000728814 hasAuthorship W2000728814A5076381011 @default.
• W2000728814 hasConcept C104317684 @default.
• W2000728814 hasConcept C11268172 @default.
• W2000728814 hasConcept C13245373 @default.
• W2000728814 hasConcept C135983454 @default.
• W2000728814 hasConcept C13965031 @default.
• W2000728814 hasConcept C155574463 @default.
• W2000728814 hasConcept C15920480 @default.
• W2000728814 hasConcept C178790620 @default.
• W2000728814 hasConcept C184651966 @default.
• W2000728814 hasConcept C185592680 @default.
• W2000728814 hasConcept C188027245 @default.
• W2000728814 hasConcept C2779820397 @default.
• W2000728814 hasConcept C521977710 @default.
• W2000728814 hasConcept C54009773 @default.
• W2000728814 hasConcept C55493867 @default.
• W2000728814 hasConcept C64237528 @default.
• W2000728814 hasConceptScore W2000728814C104317684 @default.
• W2000728814 hasConceptScore W2000728814C11268172 @default.
• W2000728814 hasConceptScore W2000728814C13245373 @default.
• W2000728814 hasConceptScore W2000728814C135983454 @default.
• W2000728814 hasConceptScore W2000728814C13965031 @default.
• W2000728814 hasConceptScore W2000728814C155574463 @default.
• W2000728814 hasConceptScore W2000728814C15920480 @default.
• W2000728814 hasConceptScore W2000728814C178790620 @default.
• W2000728814 hasConceptScore W2000728814C184651966 @default.
• W2000728814 hasConceptScore W2000728814C185592680 @default.
• W2000728814 hasConceptScore W2000728814C188027245 @default.
• W2000728814 hasConceptScore W2000728814C2779820397 @default.
• W2000728814 hasConceptScore W2000728814C521977710 @default.
• W2000728814 hasConceptScore W2000728814C54009773 @default.
• W2000728814 hasConceptScore W2000728814C55493867 @default.
• W2000728814 hasConceptScore W2000728814C64237528 @default.

• next