Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000729330> ?p ?o ?g. }
- W2000729330 endingPage "274" @default.
- W2000729330 startingPage "266" @default.
- W2000729330 abstract "Humans who carry a point mutation in the gene coding for alcohol dehydrogenase-lB (ADH1B*2; Arg47His) are markedly protected against alcoholism. Although this mutation results in a 100-fold increase in enzyme activity, it has not been reported to cause higher levels of acetaldehyde, a metabolite of ethanol known to deter alcohol intake. Hence, the mechanism by which this mutation confers protection against alcoholism is unknown. To study this protective effect, the wild-type rat cDNA encoding rADH-47Arg was mutated to encode rADH-47His, mimicking the human mutation. The mutated cDNA was incorporated into an adenoviral vector and administered to genetically selected alcohol-preferring rats. The Vmax of rADH-47His was 6-fold higher (P<0.001) than that of the wild-type rADH-47Arg. Animals transduced with rAdh-47His showed a 90% (P<0.01) increase in liver ADH activity and a 50% reduction (P< 0.001) in voluntary ethanol intake. In animals transduced with rAdh-47His, administration of ethanol (1g/kg) produced a short-lived increase of arterial blood acetaldehyde concentration to levels that were 3.5- to 5-fold greater than those in animals transduced with the wild-type rAdh-47Arg vector or with a noncoding vector. This brief increase (burst) in arterial acetaldehyde concentration after ethanol ingestion may constitute the mechanism by which humans carrying the ADH1B*2 allele are protected against alcoholism.—Rivera-Meza, M., Quin-tanilla, M. E., Tampier, L., Mura, C. V., Sapag, A., Israel, Y. Mechanism of protection against alcoholism by an alcohol dehydrogenase polymorphism: development of an animal model. FASEB J. 24, 266–274 (2010). www.fasebj.org" @default.
- W2000729330 created "2016-06-24" @default.
- W2000729330 creator A5007278420 @default.
- W2000729330 creator A5056355335 @default.
- W2000729330 creator A5057897453 @default.
- W2000729330 creator A5071751531 @default.
- W2000729330 creator A5076756295 @default.
- W2000729330 creator A5078523091 @default.
- W2000729330 date "2009-08-26" @default.
- W2000729330 modified "2023-10-18" @default.
- W2000729330 title "Mechanism of protection against alcoholism by an alcohol dehydrogenase polymorphism: development of an animal model" @default.
- W2000729330 cites W1480568644 @default.
- W2000729330 cites W1544860800 @default.
- W2000729330 cites W1588126497 @default.
- W2000729330 cites W1808728843 @default.
- W2000729330 cites W1885778179 @default.
- W2000729330 cites W1970559480 @default.
- W2000729330 cites W1974428197 @default.
- W2000729330 cites W1974883412 @default.
- W2000729330 cites W1975480828 @default.
- W2000729330 cites W1986745881 @default.
- W2000729330 cites W1992913613 @default.
- W2000729330 cites W2004500565 @default.
- W2000729330 cites W2008710752 @default.
- W2000729330 cites W2010375742 @default.
- W2000729330 cites W2010452274 @default.
- W2000729330 cites W2019499296 @default.
- W2000729330 cites W2022926298 @default.
- W2000729330 cites W2023088484 @default.
- W2000729330 cites W2025069994 @default.
- W2000729330 cites W2035596710 @default.
- W2000729330 cites W2035834158 @default.
- W2000729330 cites W2044812345 @default.
- W2000729330 cites W2046719321 @default.
- W2000729330 cites W2051081684 @default.
- W2000729330 cites W2054979333 @default.
- W2000729330 cites W2060913542 @default.
- W2000729330 cites W2063961787 @default.
- W2000729330 cites W2073253606 @default.
- W2000729330 cites W2074944043 @default.
- W2000729330 cites W2075079870 @default.
- W2000729330 cites W2092140213 @default.
- W2000729330 cites W2098264302 @default.
- W2000729330 cites W2098465498 @default.
- W2000729330 cites W2099660096 @default.
- W2000729330 cites W2122851326 @default.
- W2000729330 cites W2123535222 @default.
- W2000729330 cites W2124642123 @default.
- W2000729330 cites W2134715491 @default.
- W2000729330 cites W2148911584 @default.
- W2000729330 cites W2150450578 @default.
- W2000729330 cites W2153120191 @default.
- W2000729330 cites W2155559447 @default.
- W2000729330 cites W2155872074 @default.
- W2000729330 cites W2160690575 @default.
- W2000729330 cites W2162674639 @default.
- W2000729330 cites W2170564447 @default.
- W2000729330 cites W4253410118 @default.
- W2000729330 cites W4253422011 @default.
- W2000729330 cites W73202003 @default.
- W2000729330 doi "https://doi.org/10.1096/fj.09-132563" @default.
- W2000729330 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2797030" @default.
- W2000729330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19710201" @default.
- W2000729330 hasPublicationYear "2009" @default.
- W2000729330 type Work @default.
- W2000729330 sameAs 2000729330 @default.
- W2000729330 citedByCount "36" @default.
- W2000729330 countsByYear W20007293302012 @default.
- W2000729330 countsByYear W20007293302013 @default.
- W2000729330 countsByYear W20007293302014 @default.
- W2000729330 countsByYear W20007293302015 @default.
- W2000729330 countsByYear W20007293302016 @default.
- W2000729330 countsByYear W20007293302017 @default.
- W2000729330 countsByYear W20007293302022 @default.
- W2000729330 countsByYear W20007293302023 @default.
- W2000729330 crossrefType "journal-article" @default.
- W2000729330 hasAuthorship W2000729330A5007278420 @default.
- W2000729330 hasAuthorship W2000729330A5056355335 @default.
- W2000729330 hasAuthorship W2000729330A5057897453 @default.
- W2000729330 hasAuthorship W2000729330A5071751531 @default.
- W2000729330 hasAuthorship W2000729330A5076756295 @default.
- W2000729330 hasAuthorship W2000729330A5078523091 @default.
- W2000729330 hasBestOaLocation W20007293302 @default.
- W2000729330 hasConcept C104317684 @default.
- W2000729330 hasConcept C126322002 @default.
- W2000729330 hasConcept C134018914 @default.
- W2000729330 hasConcept C143065580 @default.
- W2000729330 hasConcept C151325109 @default.
- W2000729330 hasConcept C153911025 @default.
- W2000729330 hasConcept C181199279 @default.
- W2000729330 hasConcept C185592680 @default.
- W2000729330 hasConcept C187882448 @default.
- W2000729330 hasConcept C207583985 @default.
- W2000729330 hasConcept C2776317432 @default.
- W2000729330 hasConcept C2777344606 @default.
- W2000729330 hasConcept C2777595113 @default.
- W2000729330 hasConcept C2780161600 @default.
- W2000729330 hasConcept C2781066024 @default.