Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000730441> ?p ?o ?g. }
- W2000730441 endingPage "220" @default.
- W2000730441 startingPage "206" @default.
- W2000730441 abstract "To date, the most frequently used Parkinson’s disease (PD) biomarkers are the brain imaging measures of dopaminergic dysfunction using positron emission tomography and single photon emission computed tomography. However, major advances have occurred in the development of magnetic resonance imaging (MRI) biomarkers for PD in the past decade. Although conventional structural imaging remains normal in PD, advanced techniques have shown changes in the substantia nigra and the cortex. The most well-developed MRI markers in PD include diffusion imaging and iron load using T2/T2* relaxometry techniques. Other quantitative biomarkers such as susceptibility-weighted imaging for iron load, magnetization transfer and ultra-high-field MRI have shown great potential. More sophisticated techniques such as tractography and resting state functional connectivity give access to anatomical and functional connectivity changes in the brain, respectively. Brain perfusion can be assessed using non-contrast-agent techniques such as arterial spin labelling and spectroscopy gives access to metabolites concentrations. However, to date these techniques are not yet fully validated and standardized quantitative metrics for PD are still lacking. This review presents an overview of new structural, perfusion, metabolic and anatomo-functional connectivity biomarkers, their use in PD and their potential applications to improve the clinical diagnosis of Parkinsonian syndromes and the quality of clinical trials." @default.
- W2000730441 created "2016-06-24" @default.
- W2000730441 creator A5003399186 @default.
- W2000730441 creator A5010835736 @default.
- W2000730441 creator A5019545021 @default.
- W2000730441 creator A5029597969 @default.
- W2000730441 creator A5056572678 @default.
- W2000730441 date "2013-11-19" @default.
- W2000730441 modified "2023-10-17" @default.
- W2000730441 title "A review of the use of magnetic resonance imaging in Parkinson’s disease" @default.
- W2000730441 cites W140441464 @default.
- W2000730441 cites W1956426233 @default.
- W2000730441 cites W1963979144 @default.
- W2000730441 cites W197367273 @default.
- W2000730441 cites W1974898145 @default.
- W2000730441 cites W1977082044 @default.
- W2000730441 cites W1977761644 @default.
- W2000730441 cites W1977844107 @default.
- W2000730441 cites W1981014938 @default.
- W2000730441 cites W1982303937 @default.
- W2000730441 cites W1983432533 @default.
- W2000730441 cites W1984815968 @default.
- W2000730441 cites W1985367358 @default.
- W2000730441 cites W1985613988 @default.
- W2000730441 cites W1986382203 @default.
- W2000730441 cites W1989555449 @default.
- W2000730441 cites W1992791394 @default.
- W2000730441 cites W1994802648 @default.
- W2000730441 cites W1996271059 @default.
- W2000730441 cites W1997147102 @default.
- W2000730441 cites W1998996817 @default.
- W2000730441 cites W1999514395 @default.
- W2000730441 cites W1999653836 @default.
- W2000730441 cites W2000104977 @default.
- W2000730441 cites W2001285351 @default.
- W2000730441 cites W2006517335 @default.
- W2000730441 cites W2007279520 @default.
- W2000730441 cites W2007581301 @default.
- W2000730441 cites W2009494091 @default.
- W2000730441 cites W2009546549 @default.
- W2000730441 cites W2009927375 @default.
- W2000730441 cites W2012458230 @default.
- W2000730441 cites W2012769853 @default.
- W2000730441 cites W2013987640 @default.
- W2000730441 cites W2014754992 @default.
- W2000730441 cites W2015936929 @default.
- W2000730441 cites W2016250122 @default.
- W2000730441 cites W2020975638 @default.
- W2000730441 cites W2023630108 @default.
- W2000730441 cites W2024024471 @default.
- W2000730441 cites W2026188739 @default.
- W2000730441 cites W2029817323 @default.
- W2000730441 cites W2032254014 @default.
- W2000730441 cites W2032980536 @default.
- W2000730441 cites W2033109865 @default.
- W2000730441 cites W2034761873 @default.
- W2000730441 cites W2036740787 @default.
- W2000730441 cites W2038343139 @default.
- W2000730441 cites W2044940345 @default.
- W2000730441 cites W2047523747 @default.
- W2000730441 cites W2048345503 @default.
- W2000730441 cites W2053606755 @default.
- W2000730441 cites W2053919734 @default.
- W2000730441 cites W2054130199 @default.
- W2000730441 cites W2056061278 @default.
- W2000730441 cites W2056291378 @default.
- W2000730441 cites W2056361646 @default.
- W2000730441 cites W2059159151 @default.
- W2000730441 cites W2060416311 @default.
- W2000730441 cites W2060899536 @default.
- W2000730441 cites W2062492266 @default.
- W2000730441 cites W2063920647 @default.
- W2000730441 cites W2066270247 @default.
- W2000730441 cites W2066777502 @default.
- W2000730441 cites W2069339609 @default.
- W2000730441 cites W2075050732 @default.
- W2000730441 cites W2076182555 @default.
- W2000730441 cites W2076342549 @default.
- W2000730441 cites W2078860848 @default.
- W2000730441 cites W2079721432 @default.
- W2000730441 cites W2084691579 @default.
- W2000730441 cites W2086361121 @default.
- W2000730441 cites W2087866471 @default.
- W2000730441 cites W2089172752 @default.
- W2000730441 cites W2089351022 @default.
- W2000730441 cites W2089940272 @default.
- W2000730441 cites W2090215580 @default.
- W2000730441 cites W2091385965 @default.
- W2000730441 cites W2093459949 @default.
- W2000730441 cites W2094035520 @default.
- W2000730441 cites W2094790509 @default.
- W2000730441 cites W2095187500 @default.
- W2000730441 cites W2095431003 @default.
- W2000730441 cites W2098703664 @default.
- W2000730441 cites W2101249624 @default.
- W2000730441 cites W2101935744 @default.
- W2000730441 cites W2109548318 @default.
- W2000730441 cites W2110109740 @default.