FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000731858> ?p ?o ?g. }

• W2000731858 endingPage "871" @default.
• W2000731858 startingPage "859" @default.
• W2000731858 abstract "The mTOR kinase controls cell growth, proliferation, and survival through two distinct multiprotein complexes, mTORC1 and mTORC2. mTOR and mLST8 are in both complexes, while raptor and rictor are part of only mTORC1 and mTORC2, respectively. To investigate mTORC1 and mTORC2 function in vivo, we generated mice deficient for raptor, rictor, or mLST8. Like mice null for mTOR, those lacking raptor die early in development. However, mLST8 null embryos survive until e10.5 and resemble embryos missing rictor. mLST8 is necessary to maintain the rictor-mTOR, but not the raptor-mTOR, interaction, and both mLST8 and rictor are required for the hydrophobic motif phosphorylation of Akt/PKB and PKCα, but not S6K1. Furthermore, insulin signaling to FOXO3, but not to TSC2 or GSK3β, requires mLST8 and rictor. Thus, mTORC1 function is essential in early development, mLST8 is required only for mTORC2 signaling, and mTORC2 is a necessary component of the Akt-FOXO and PKCα pathways." @default.
• W2000731858 created "2016-06-24" @default.
• W2000731858 creator A5013582936 @default.
• W2000731858 creator A5016604512 @default.
• W2000731858 creator A5025860174 @default.
• W2000731858 creator A5048027093 @default.
• W2000731858 creator A5053515605 @default.
• W2000731858 creator A5060237256 @default.
• W2000731858 creator A5060331261 @default.
• W2000731858 creator A5066371227 @default.
• W2000731858 creator A5086112491 @default.
• W2000731858 date "2006-12-01" @default.
• W2000731858 modified "2023-10-10" @default.
• W2000731858 title "Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1" @default.
• W2000731858 cites W1668086213 @default.
• W2000731858 cites W1726025741 @default.
• W2000731858 cites W1983698019 @default.
• W2000731858 cites W1985850927 @default.
• W2000731858 cites W1996430165 @default.
• W2000731858 cites W2001259221 @default.
• W2000731858 cites W2005018138 @default.
• W2000731858 cites W2005359040 @default.
• W2000731858 cites W2005496215 @default.
• W2000731858 cites W2006559495 @default.
• W2000731858 cites W2012297570 @default.
• W2000731858 cites W2023012828 @default.
• W2000731858 cites W2026987638 @default.
• W2000731858 cites W2035648799 @default.
• W2000731858 cites W2052583546 @default.
• W2000731858 cites W2053073281 @default.
• W2000731858 cites W2056891806 @default.
• W2000731858 cites W2060905299 @default.
• W2000731858 cites W2065887259 @default.
• W2000731858 cites W2082770517 @default.
• W2000731858 cites W2100782033 @default.
• W2000731858 cites W2102653975 @default.
• W2000731858 cites W2105048034 @default.
• W2000731858 cites W2117028091 @default.
• W2000731858 cites W2131426434 @default.
• W2000731858 cites W2137563421 @default.
• W2000731858 cites W2140439371 @default.
• W2000731858 cites W2141424872 @default.
• W2000731858 cites W2142060283 @default.
• W2000731858 cites W2144059623 @default.
• W2000731858 cites W2144323242 @default.
• W2000731858 cites W2145497092 @default.
• W2000731858 cites W2148785089 @default.
• W2000731858 cites W2152289580 @default.
• W2000731858 cites W2152600551 @default.
• W2000731858 cites W2159993610 @default.
• W2000731858 cites W2163018106 @default.
• W2000731858 cites W2165541514 @default.
• W2000731858 cites W2167839699 @default.
• W2000731858 cites W2168147607 @default.
• W2000731858 cites W2168375708 @default.
• W2000731858 cites W2169980814 @default.
• W2000731858 cites W4238567307 @default.
• W2000731858 doi "https://doi.org/10.1016/j.devcel.2006.10.007" @default.
• W2000731858 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17141160" @default.
• W2000731858 hasPublicationYear "2006" @default.
• W2000731858 type Work @default.
• W2000731858 sameAs 2000731858 @default.
• W2000731858 citedByCount "1288" @default.
• W2000731858 countsByYear W20007318582012 @default.
• W2000731858 countsByYear W20007318582013 @default.
• W2000731858 countsByYear W20007318582014 @default.
• W2000731858 countsByYear W20007318582015 @default.
• W2000731858 countsByYear W20007318582016 @default.
• W2000731858 countsByYear W20007318582017 @default.
• W2000731858 countsByYear W20007318582018 @default.
• W2000731858 countsByYear W20007318582019 @default.
• W2000731858 countsByYear W20007318582020 @default.
• W2000731858 countsByYear W20007318582021 @default.
• W2000731858 countsByYear W20007318582022 @default.
• W2000731858 countsByYear W20007318582023 @default.
• W2000731858 crossrefType "journal-article" @default.
• W2000731858 hasAuthorship W2000731858A5013582936 @default.
• W2000731858 hasAuthorship W2000731858A5016604512 @default.
• W2000731858 hasAuthorship W2000731858A5025860174 @default.
• W2000731858 hasAuthorship W2000731858A5048027093 @default.
• W2000731858 hasAuthorship W2000731858A5053515605 @default.
• W2000731858 hasAuthorship W2000731858A5060237256 @default.
• W2000731858 hasAuthorship W2000731858A5060331261 @default.
• W2000731858 hasAuthorship W2000731858A5066371227 @default.
• W2000731858 hasAuthorship W2000731858A5086112491 @default.
• W2000731858 hasBestOaLocation W20007318581 @default.
• W2000731858 hasConcept C104202773 @default.
• W2000731858 hasConcept C107846503 @default.
• W2000731858 hasConcept C168003608 @default.
• W2000731858 hasConcept C502942594 @default.
• W2000731858 hasConcept C62478195 @default.
• W2000731858 hasConcept C75217442 @default.
• W2000731858 hasConcept C86554907 @default.
• W2000731858 hasConcept C86803240 @default.
• W2000731858 hasConcept C95444343 @default.
• W2000731858 hasConcept C98490376 @default.
• W2000731858 hasConceptScore W2000731858C104202773 @default.
• W2000731858 hasConceptScore W2000731858C107846503 @default.

• next