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- W2000731919 abstract "Abstract. The pathogenesis of the acute porphyric attack is not known. One hypothesis is that porphyrin precursors, especially 5-aminolaevulinic acid (ALA), are toxic for neuronal tissue. This was tested by infusing ALA in a male volunteer after a loading dose at a rate of 50–80 mg h-1 for 92.5 h. During the experiment plasma ALA concentration was 9.11 μmol 1-1 and porphobilinogen concentration 3–6 μmol 1-1 which are the levels seen during acute attacks. Urinary excretion of these porphyrin precursors was also markedly increased. ALA infusion caused no subjective symptoms and no change in pulse rate, blood pressure, or autonomic nerve function or conduction velocity of peripheral nerves. Photosensitivity was not demonstrable. It is concluded that sustained high plasma ALA concentration does not cause porphyria-like symptoms." @default.
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- W2000731919 date "1992-06-01" @default.
- W2000731919 modified "2023-10-18" @default.
- W2000731919 title "Sustained high plasma 5-aminolaevulinic acid concentration in a volunteer: no porphyric symptoms" @default.
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- W2000731919 doi "https://doi.org/10.1111/j.1365-2362.1992.tb01482.x" @default.
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