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- W2000732112 abstract "Green tea (Camellia sinensis) is rich in catechins, of which (-)-epigallocatechin-3-gallate (EGCG) is the most abundant. Studies in animal models of carcinogenesis have shown that green tea and EGCG can inhibit tumorigenesis during the initiation, promotion and progression stages. Many potential mechanisms have been proposed including both antioxidant and pro-oxidant effects, but questions remain regarding the relevance of these mechanisms to cancer prevention. In the present review, we will discuss the redox chemistry of the tea catechins and the current literature on the antioxidant and pro-oxidative effects of the green tea polyphenols as they relate to cancer prevention. We report that although the catechins are chemical antioxidants which can quench free radical species and chelate transition metals, there is evidence that some of the effects of these compounds may be related to induction of oxidative stress. Such pro-oxidant effects appear to be responsible for the induction of apoptosis in tumor cells. These pro-oxidant effects may also induce endogenous antioxidant systems in normal tissues that offer protection against carcinogenic insult. This review is meant point out understudied areas and stimulate research on the topic with the hope that insights into the mechanisms of cancer preventive activity of tea polyphenols will result." @default.
- W2000732112 created "2016-06-24" @default.
- W2000732112 creator A5061642819 @default.
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- W2000732112 date "2010-09-01" @default.
- W2000732112 modified "2023-10-13" @default.
- W2000732112 title "The antioxidant and pro-oxidant activities of green tea polyphenols: A role in cancer prevention" @default.
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- W2000732112 doi "https://doi.org/10.1016/j.abb.2010.06.013" @default.
- W2000732112 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2946098" @default.
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