FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000732921> ?p ?o ?g. }

• W2000732921 endingPage "301" @default.
• W2000732921 startingPage "289" @default.
• W2000732921 abstract "It is known that flavonoids possess, among others, antioxidant and antitumoral properties that depend on their molecular structure. The central objective if this study was to investigate the potential antioxidant and antiproliferative properties of the flavonol morin and its new oxovanadium(IV) complex (VOmor) that was synthesized in order to modify the morin chemical structure. Two osteoblast (UMR106 and MC3T3E1), two breast tumor (T47D and SKBR3) and breast epithelial cell lines in culture were used for the antitumoral determinations. Additionally, a comparative study of their antioxidant capacities using different radicals (DPPH, ABTS+, OH, O2−, ROO) was performed. Selected mechanisms of action were studied using the breast cancer cell lines. Results obtained show that morin and its complex behaved as good antioxidant agents for some of the radicals and that the complexation improved the behavior with respect to OH and O2− radicals being morin more effective as ROO scavenger. A considerable variation in sensitivity was observed in the breast cancer cells but non-specificity was found for the treatment of osteosarcoma. Moreover, the compounds did not affect the normal proliferation of the breast epithelial mammal cells. The mechanistic studies demonstrated that the complex did not generate reactive oxygen species in the cells (confirming the in vitro studies) and did not produce any damage of DNA. The plasmatic membrane was observed to be damaged only in the SKBR3 cell line. In contrast, the perturbation of the mitochondrial membrane potential and the activation of caspase 3/7 for the breast tumor cells revealed an apoptotic cell death process. All these results collectively suggested that VOmor complex could serve as promising pharmacologically active substance against breast cancer treatment." @default.
• W2000732921 created "2016-06-24" @default.
• W2000732921 creator A5000852688 @default.
• W2000732921 creator A5005945570 @default.
• W2000732921 creator A5012911399 @default.
• W2000732921 creator A5030957246 @default.
• W2000732921 creator A5041866710 @default.
• W2000732921 creator A5044311182 @default.
• W2000732921 creator A5050679388 @default.
• W2000732921 creator A5051331376 @default.
• W2000732921 creator A5075964566 @default.
• W2000732921 date "2013-11-01" @default.
• W2000732921 modified "2023-10-09" @default.
• W2000732921 title "Biological evaluation of morin and its new oxovanadium(IV) complex as antio-xidant and specific anti-cancer agents" @default.
• W2000732921 cites W1968038894 @default.
• W2000732921 cites W1972426232 @default.
• W2000732921 cites W1975165348 @default.
• W2000732921 cites W1978726038 @default.
• W2000732921 cites W1990939007 @default.
• W2000732921 cites W1992194283 @default.
• W2000732921 cites W1995809816 @default.
• W2000732921 cites W1996545551 @default.
• W2000732921 cites W2003912750 @default.
• W2000732921 cites W2010339535 @default.
• W2000732921 cites W2015276173 @default.
• W2000732921 cites W2018849227 @default.
• W2000732921 cites W2019586341 @default.
• W2000732921 cites W2037045527 @default.
• W2000732921 cites W2039786178 @default.
• W2000732921 cites W2040660669 @default.
• W2000732921 cites W2042158095 @default.
• W2000732921 cites W2048024271 @default.
• W2000732921 cites W2050708554 @default.
• W2000732921 cites W2055020674 @default.
• W2000732921 cites W2056319741 @default.
• W2000732921 cites W2058222760 @default.
• W2000732921 cites W2063834712 @default.
• W2000732921 cites W2064385507 @default.
• W2000732921 cites W2067353941 @default.
• W2000732921 cites W2068453481 @default.
• W2000732921 cites W2072017399 @default.
• W2000732921 cites W2082501904 @default.
• W2000732921 cites W2082865189 @default.
• W2000732921 cites W2083661119 @default.
• W2000732921 cites W2084067983 @default.
• W2000732921 cites W2086959952 @default.
• W2000732921 cites W2089370460 @default.
• W2000732921 cites W2089721932 @default.
• W2000732921 cites W2103499253 @default.
• W2000732921 cites W2103719674 @default.
• W2000732921 cites W2114781275 @default.
• W2000732921 cites W2116060738 @default.
• W2000732921 cites W2138562665 @default.
• W2000732921 cites W2149742108 @default.
• W2000732921 cites W2158944838 @default.
• W2000732921 cites W2226001858 @default.
• W2000732921 cites W4210762988 @default.
• W2000732921 cites W4253134632 @default.
• W2000732921 cites W4293247451 @default.
• W2000732921 doi "https://doi.org/10.1016/j.cbi.2013.10.006" @default.
• W2000732921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24125835" @default.
• W2000732921 hasPublicationYear "2013" @default.
• W2000732921 type Work @default.
• W2000732921 sameAs 2000732921 @default.
• W2000732921 citedByCount "56" @default.
• W2000732921 countsByYear W20007329212014 @default.
• W2000732921 countsByYear W20007329212015 @default.
• W2000732921 countsByYear W20007329212016 @default.
• W2000732921 countsByYear W20007329212017 @default.
• W2000732921 countsByYear W20007329212018 @default.
• W2000732921 countsByYear W20007329212019 @default.
• W2000732921 countsByYear W20007329212020 @default.
• W2000732921 countsByYear W20007329212021 @default.
• W2000732921 countsByYear W20007329212022 @default.
• W2000732921 countsByYear W20007329212023 @default.
• W2000732921 crossrefType "journal-article" @default.
• W2000732921 hasAuthorship W2000732921A5000852688 @default.
• W2000732921 hasAuthorship W2000732921A5005945570 @default.
• W2000732921 hasAuthorship W2000732921A5012911399 @default.
• W2000732921 hasAuthorship W2000732921A5030957246 @default.
• W2000732921 hasAuthorship W2000732921A5041866710 @default.
• W2000732921 hasAuthorship W2000732921A5044311182 @default.
• W2000732921 hasAuthorship W2000732921A5050679388 @default.
• W2000732921 hasAuthorship W2000732921A5051331376 @default.
• W2000732921 hasAuthorship W2000732921A5075964566 @default.
• W2000732921 hasConcept C121608353 @default.
• W2000732921 hasConcept C126322002 @default.
• W2000732921 hasConcept C139066938 @default.
• W2000732921 hasConcept C142724271 @default.
• W2000732921 hasConcept C185592680 @default.
• W2000732921 hasConcept C190283241 @default.
• W2000732921 hasConcept C191560914 @default.
• W2000732921 hasConcept C2778004101 @default.
• W2000732921 hasConcept C2779968248 @default.
• W2000732921 hasConcept C2781031786 @default.
• W2000732921 hasConcept C2781401929 @default.
• W2000732921 hasConcept C2994423619 @default.
• W2000732921 hasConcept C48349386 @default.

• next