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• W2000732973 abstract "The effect of the incorporation of 5-bromodeoxyuridine (BUdR) in the DNA of T cells on radiosensitivity after irradiation with X-rays and with ultraviolet light has been studied. Radiation survival decreased both after X-ray and ultraviolet light. BUdR incorporation into T cells causes a lengthening of the cell cycle which could be attributed to selective increases of the G1 and S phases. This change in age distribution of the cells might slightly affect the radiosensitivity based on survival. The incorporation of BUdR during one generation cycle before X-irradiation caused an increase in the induction of breaks in the 5-bromouracil (BU)-containing strand over those found in the opposite strand of DNA from the same cells. This increased break induction was found only after X-irradiation and treatment with high concentrations of BUdR. The induction of breaks in both strands was always linear with dose. Irradiation with ultraviolet light produced practically no induction of breaks in normal T cells. After e..." @default.
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• W2000732973 date "1972-12-01" @default.
• W2000732973 modified "2023-09-29" @default.
• W2000732973 title "The Influence of 5-Bromodeoxyuridine on the Induction of Breaks in the Deoxyribonucleic Acid of Cultivated Human Cells by X-Irradiation and Ultraviolet Light" @default.
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• W2000732973 doi "https://doi.org/10.2307/3573520" @default.
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