Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000734043> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2000734043 endingPage "695" @default.
- W2000734043 startingPage "690" @default.
- W2000734043 abstract "Lyme disease is caused byBorrelia burgdorferi.Human plasminogen and urokinase-type plasminogen activator bind to the surface of the spirochete where plasmin is generated. We have suggested that bound urokinase and plasminogen are utilized by the organism to disseminate. We tested whether the physiological inhibitors of urokinase, plasminogen activator inhibitor-1 and -2 (PAI-1, PAI-2), could regulate the activity of spirochete-bound urokinase. Thekassof PAI-1 and PAI-2 for bound urokinase were 1.3 × 106M−1s−1and 6.9 × 104M−1s−1, respectively, whereas thekassfor free urokinase were 7.2 × 106M−1s−1and 5.3 × 105M−1s−1, respectively. Plasmin associated with the spirochete was not inhibited by α2-antiplasmin. These results suggest that PAI-1, PAI-2 and α2-antiplasmin would not be efficient regulators of fibrinolytic protease activity on theBorrelialsurface and would not pose a barrier to utilization of these enzymes for dissemination in the human host." @default.
- W2000734043 created "2016-06-24" @default.
- W2000734043 creator A5000203706 @default.
- W2000734043 creator A5017058881 @default.
- W2000734043 creator A5042075267 @default.
- W2000734043 date "1996-02-01" @default.
- W2000734043 modified "2023-09-23" @default.
- W2000734043 title "Inhibition ofBorrelia burgdorferi-Bound Fibrinolytic Enzymes by α2-Antiplasmin, PAI-1 and PAI-2" @default.
- W2000734043 doi "https://doi.org/10.1006/bbrc.1996.0296" @default.
- W2000734043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8645243" @default.
- W2000734043 hasPublicationYear "1996" @default.
- W2000734043 type Work @default.
- W2000734043 sameAs 2000734043 @default.
- W2000734043 citedByCount "18" @default.
- W2000734043 countsByYear W20007340432014 @default.
- W2000734043 countsByYear W20007340432018 @default.
- W2000734043 countsByYear W20007340432022 @default.
- W2000734043 crossrefType "journal-article" @default.
- W2000734043 hasAuthorship W2000734043A5000203706 @default.
- W2000734043 hasAuthorship W2000734043A5017058881 @default.
- W2000734043 hasAuthorship W2000734043A5042075267 @default.
- W2000734043 hasConcept C126322002 @default.
- W2000734043 hasConcept C134018914 @default.
- W2000734043 hasConcept C153911025 @default.
- W2000734043 hasConcept C159654299 @default.
- W2000734043 hasConcept C181199279 @default.
- W2000734043 hasConcept C185592680 @default.
- W2000734043 hasConcept C203014093 @default.
- W2000734043 hasConcept C2776714187 @default.
- W2000734043 hasConcept C2776825266 @default.
- W2000734043 hasConcept C2776892390 @default.
- W2000734043 hasConcept C2779159148 @default.
- W2000734043 hasConcept C2779679481 @default.
- W2000734043 hasConcept C2781071845 @default.
- W2000734043 hasConcept C54355233 @default.
- W2000734043 hasConcept C55493867 @default.
- W2000734043 hasConcept C71924100 @default.
- W2000734043 hasConcept C86803240 @default.
- W2000734043 hasConcept C89423630 @default.
- W2000734043 hasConceptScore W2000734043C126322002 @default.
- W2000734043 hasConceptScore W2000734043C134018914 @default.
- W2000734043 hasConceptScore W2000734043C153911025 @default.
- W2000734043 hasConceptScore W2000734043C159654299 @default.
- W2000734043 hasConceptScore W2000734043C181199279 @default.
- W2000734043 hasConceptScore W2000734043C185592680 @default.
- W2000734043 hasConceptScore W2000734043C203014093 @default.
- W2000734043 hasConceptScore W2000734043C2776714187 @default.
- W2000734043 hasConceptScore W2000734043C2776825266 @default.
- W2000734043 hasConceptScore W2000734043C2776892390 @default.
- W2000734043 hasConceptScore W2000734043C2779159148 @default.
- W2000734043 hasConceptScore W2000734043C2779679481 @default.
- W2000734043 hasConceptScore W2000734043C2781071845 @default.
- W2000734043 hasConceptScore W2000734043C54355233 @default.
- W2000734043 hasConceptScore W2000734043C55493867 @default.
- W2000734043 hasConceptScore W2000734043C71924100 @default.
- W2000734043 hasConceptScore W2000734043C86803240 @default.
- W2000734043 hasConceptScore W2000734043C89423630 @default.
- W2000734043 hasIssue "3" @default.
- W2000734043 hasLocation W20007340431 @default.
- W2000734043 hasLocation W20007340432 @default.
- W2000734043 hasOpenAccess W2000734043 @default.
- W2000734043 hasPrimaryLocation W20007340431 @default.
- W2000734043 hasRelatedWork W1637066680 @default.
- W2000734043 hasRelatedWork W189462138 @default.
- W2000734043 hasRelatedWork W2000734043 @default.
- W2000734043 hasRelatedWork W2012378993 @default.
- W2000734043 hasRelatedWork W2014249782 @default.
- W2000734043 hasRelatedWork W2038747404 @default.
- W2000734043 hasRelatedWork W2076555229 @default.
- W2000734043 hasRelatedWork W2433598040 @default.
- W2000734043 hasRelatedWork W2805430304 @default.
- W2000734043 hasRelatedWork W4319916489 @default.
- W2000734043 hasVolume "219" @default.
- W2000734043 isParatext "false" @default.
- W2000734043 isRetracted "false" @default.
- W2000734043 magId "2000734043" @default.
- W2000734043 workType "article" @default.