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• W2000734150 abstract "Blood mononuclear leukocytes from multiple sclerosis (MS) patients were evaluated for reactivity to α- or γ-interferon (IFN), using a response whereby IFN-treated (primed) cells synthesize higher levels of IFN than untreated cells. Leukocytes were treated in vitro with natural α-IFN, recombinant α-IFN, recombinant γ-IFN, or no IFN, then exposed to measles virus to induce IFN synthesis. With no IFN treatment, IFN production by cells from the MS patients was significantly less than nomral (P ≤ 0.025). However, with IFN treatment, cells from MS patients were primed as well as cells from normal controls: IFN synthesis for the MS patients' cells was increased 10–11-fold with either α-IFN preparation and 3.6-fold with γ-IFN. These findings verify the presence of leukocyte reactivity to α-IFN and provide the first demonstration of responsiveness to γ-IFN in MS. Blood mononuclear leukocytes from multiple sclerosis (MS) patients were evaluated for reactivity to α- or γ-interferon (IFN), using a response whereby IFN-treated (primed) cells synthesize higher levels of IFN than untreated cells. Leukocytes were treated in vitro with natural α-IFN, recombinant α-IFN, recombinant γ-IFN, or no IFN, then exposed to measles virus to induce IFN synthesis. With no IFN treatment, IFN production by cells from the MS patients was significantly less than nomral (P ≤ 0.025). However, with IFN treatment, cells from MS patients were primed as well as cells from normal controls: IFN synthesis for the MS patients' cells was increased 10–11-fold with either α-IFN preparation and 3.6-fold with γ-IFN. These findings verify the presence of leukocyte reactivity to α-IFN and provide the first demonstration of responsiveness to γ-IFN in MS." @default.
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• W2000734150 date "1985-01-01" @default.
• W2000734150 modified "2023-10-18" @default.
• W2000734150 title "Leukocytes from multiple sclerosis patients respond to α- and γ-interferons" @default.
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• W2000734150 doi "https://doi.org/10.1016/s0165-5728(85)80020-5" @default.
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