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- W2000734498 abstract "This themed section of BJP includes 11 reviews on the biology of G‐protein coupled receptors (GPCRs) and the drug targets that these present, 21 research papers on the pharmacology of a range of GPCRs and Commentaries on four of the papers. Areas reviewed include molecular interactions, particular in respect of hetero‐dimerisation between receptors and other membrane‐located proteins and other key signalling molecules including cAMP and G12/13 proteins and recently de‐orphanised receptors including the Neuromedins U & S and the Free Fatty Acid receptors FFA2 & FFA3. The research papers cover the pharmacology of a range of agents acting at GPCRs, including adrenoceptors, purinoceptors, 5HT, opioid, cannabinoid & PAR‐2 receptors. A group of papers is concerned with the interesting and rapidly developing pharmacology of drugs acting at β 2 ‐adrenoceptors. The reach of GPCRs is illustrated by the range of physiological systems and therapeutic applications involved, including pain, cancer, cardiovascular, gastrointestinal, visual and respiratory and central nervous systems." @default.
- W2000734498 created "2016-06-24" @default.
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- W2000734498 date "2009-08-25" @default.
- W2000734498 modified "2023-09-25" @default.
- W2000734498 title "GPCR Theme Editorial" @default.
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- W2000734498 doi "https://doi.org/10.1111/j.1476-5381.2009.00422.x" @default.
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