FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000734643> ?p ?o ?g. }

• W2000734643 abstract "Abstract Background Bmi1 has been identified as an important regulator in breast cancer, but its relationship with other signaling molecules such as ERα and HER2 is undetermined. Methods The expression of Bmi1 and its correlation with ERα, PR, Ki-67, HER2, p16 INK4a , cyclin D1 and pRB was evaluated by immunohistochemistry in a collection of 92 cases of breast cancer and statistically analyzed. Stimulation of Bmi1 expression by ERα or 17β-estradiol (E2) was analyzed in cell lines including MCF-7, MDA-MB-231, ERα-restored MDA-MB-231 and ERα-knockdown MCF-7 cells. Luciferase reporter and chromatin immunoprecipitation assays were also performed. Results Immunostaining revealed strong correlation of Bmi1 and ERα expression status in breast cancer. Expression of Bmi1 was stimulated by 17β-estradiol in ERα-positive MCF-7 cells but not in ERα-negative MDA-MB-231 cells, while the expression of Bmi1 did not alter expression of ERα. As expected, stimulation of Bmi1 expression could also be achieved in ERα-restored MDA-MB-231 cells, and at the same time depletion of ERα decreased expression of Bmi1. The proximal promoter region of Bmi1 was transcriptionally activated with co-transfection of ERα in luciferase assays, and the interaction of the Bmi1 promoter with ERα was confirmed by chromatin immunoprecipitation. Moreover, in breast cancer tissues activation of the ERα-coupled Bmi1 pathway generally correlated with high levels of cyclin D1, while loss of its activity resulted in aberrant expression of p16 INK4a and a high Ki-67 index, which implied a more aggressive phenotype of breast cancer. Conclusions Expression of Bmi1 is influenced by ERα, and the activity of the ERα-coupled Bmi1 signature impacts p16 INK4a and cyclin D1 status and thus correlates with the tumor molecular subtype and biologic behavior. This demonstrates the important role which is played by ERα-coupled Bmi1 in human breast cancer." @default.
• W2000734643 created "2016-06-24" @default.
• W2000734643 creator A5002731614 @default.
• W2000734643 creator A5022526821 @default.
• W2000734643 creator A5036604191 @default.
• W2000734643 creator A5037794174 @default.
• W2000734643 creator A5038228419 @default.
• W2000734643 creator A5041492237 @default.
• W2000734643 creator A5045831121 @default.
• W2000734643 creator A5056621420 @default.
• W2000734643 creator A5068880281 @default.
• W2000734643 creator A5069849278 @default.
• W2000734643 creator A5074093223 @default.
• W2000734643 creator A5084908849 @default.
• W2000734643 date "2014-02-24" @default.
• W2000734643 modified "2023-10-18" @default.
• W2000734643 title "Estrogen receptor α-coupled Bmi1 regulation pathway in breast cancer and its clinical implications" @default.
• W2000734643 cites W1961026612 @default.
• W2000734643 cites W1974904178 @default.
• W2000734643 cites W1977289089 @default.
• W2000734643 cites W1979721685 @default.
• W2000734643 cites W1983104192 @default.
• W2000734643 cites W1984893300 @default.
• W2000734643 cites W1986348049 @default.
• W2000734643 cites W1997393527 @default.
• W2000734643 cites W1998242092 @default.
• W2000734643 cites W2007161335 @default.
• W2000734643 cites W2013956549 @default.
• W2000734643 cites W2014546230 @default.
• W2000734643 cites W2016203922 @default.
• W2000734643 cites W2019406647 @default.
• W2000734643 cites W2022452105 @default.
• W2000734643 cites W2022557585 @default.
• W2000734643 cites W2032062839 @default.
• W2000734643 cites W2032474891 @default.
• W2000734643 cites W2036713409 @default.
• W2000734643 cites W2052306492 @default.
• W2000734643 cites W2053840813 @default.
• W2000734643 cites W2079651105 @default.
• W2000734643 cites W2087172939 @default.
• W2000734643 cites W2093364695 @default.
• W2000734643 cites W2095536388 @default.
• W2000734643 cites W2101114008 @default.
• W2000734643 cites W2101940777 @default.
• W2000734643 cites W2111369086 @default.
• W2000734643 cites W2114641334 @default.
• W2000734643 cites W2118194236 @default.
• W2000734643 cites W2126889841 @default.
• W2000734643 cites W2132893003 @default.
• W2000734643 cites W2137853125 @default.
• W2000734643 cites W2150134401 @default.
• W2000734643 cites W2150821966 @default.
• W2000734643 cites W2151365391 @default.
• W2000734643 cites W2154128690 @default.
• W2000734643 cites W2156583045 @default.
• W2000734643 cites W2167724857 @default.
• W2000734643 cites W2170086508 @default.
• W2000734643 cites W2288763477 @default.
• W2000734643 doi "https://doi.org/10.1186/1471-2407-14-122" @default.
• W2000734643 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3939403" @default.
• W2000734643 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24559156" @default.
• W2000734643 hasPublicationYear "2014" @default.
• W2000734643 type Work @default.
• W2000734643 sameAs 2000734643 @default.
• W2000734643 citedByCount "13" @default.
• W2000734643 countsByYear W20007346432015 @default.
• W2000734643 countsByYear W20007346432016 @default.
• W2000734643 countsByYear W20007346432017 @default.
• W2000734643 countsByYear W20007346432018 @default.
• W2000734643 countsByYear W20007346432020 @default.
• W2000734643 countsByYear W20007346432021 @default.
• W2000734643 countsByYear W20007346432022 @default.
• W2000734643 crossrefType "journal-article" @default.
• W2000734643 hasAuthorship W2000734643A5002731614 @default.
• W2000734643 hasAuthorship W2000734643A5022526821 @default.
• W2000734643 hasAuthorship W2000734643A5036604191 @default.
• W2000734643 hasAuthorship W2000734643A5037794174 @default.
• W2000734643 hasAuthorship W2000734643A5038228419 @default.
• W2000734643 hasAuthorship W2000734643A5041492237 @default.
• W2000734643 hasAuthorship W2000734643A5045831121 @default.
• W2000734643 hasAuthorship W2000734643A5056621420 @default.
• W2000734643 hasAuthorship W2000734643A5068880281 @default.
• W2000734643 hasAuthorship W2000734643A5069849278 @default.
• W2000734643 hasAuthorship W2000734643A5074093223 @default.
• W2000734643 hasAuthorship W2000734643A5084908849 @default.
• W2000734643 hasBestOaLocation W20007346431 @default.
• W2000734643 hasConcept C101762097 @default.
• W2000734643 hasConcept C104317684 @default.
• W2000734643 hasConcept C121608353 @default.
• W2000734643 hasConcept C126322002 @default.
• W2000734643 hasConcept C134320426 @default.
• W2000734643 hasConcept C150194340 @default.
• W2000734643 hasConcept C173396325 @default.
• W2000734643 hasConcept C199835354 @default.
• W2000734643 hasConcept C2778987575 @default.
• W2000734643 hasConcept C29537977 @default.
• W2000734643 hasConcept C502942594 @default.
• W2000734643 hasConcept C530470458 @default.
• W2000734643 hasConcept C54355233 @default.
• W2000734643 hasConcept C55493867 @default.

• next