Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000736294> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2000736294 endingPage "1365" @default.
- W2000736294 startingPage "1357" @default.
- W2000736294 abstract "Series of experiments aimed at a primary pharmaco-toxicological evaluation of 2-iodomelatonin, a high-affinity melatonin analogue, were performed. In the rat ovulation-inhibition model, 2-iodomelatonin was much more potent than either melatonin or 6-chloromelatonin. The acute toxicity was extremely low and close to, though slightly higher than that reported previously for melatonin. In the rat, 2-iodomelatonin was slowly metabolized in vivo; its apparent elimination half-life was about 60 minutes, much longer than that reported for melatonin. The in vitro mutagenesis tests demonstrated clearly that 2-iodomelatonin in concentrations, exceeding the dose range employed in the in vivo studies, was actually devoid of mutagenic effects. The obtained results suggest that 2-iodomelatonin deserves a detailed pharmaco-toxicological evaluation and could be eventually used in pharmacokinetic and pharmacodynamic studies in humans." @default.
- W2000736294 created "2016-06-24" @default.
- W2000736294 creator A5013413844 @default.
- W2000736294 creator A5022470178 @default.
- W2000736294 creator A5027019614 @default.
- W2000736294 creator A5052124556 @default.
- W2000736294 creator A5057311540 @default.
- W2000736294 creator A5072010155 @default.
- W2000736294 creator A5072010198 @default.
- W2000736294 date "1993-01-01" @default.
- W2000736294 modified "2023-09-25" @default.
- W2000736294 title "Primary pharmaco-toxicological evaluation of 2-iodomelatonin, a potent melatonin agonist" @default.
- W2000736294 cites W1495842154 @default.
- W2000736294 cites W154194792 @default.
- W2000736294 cites W1979018464 @default.
- W2000736294 cites W1982083438 @default.
- W2000736294 cites W2005156172 @default.
- W2000736294 cites W2009032550 @default.
- W2000736294 cites W2012988676 @default.
- W2000736294 cites W2019322506 @default.
- W2000736294 cites W2022688636 @default.
- W2000736294 cites W2024449200 @default.
- W2000736294 cites W2034551798 @default.
- W2000736294 cites W2038305850 @default.
- W2000736294 cites W2052568531 @default.
- W2000736294 cites W2055732421 @default.
- W2000736294 cites W2091646716 @default.
- W2000736294 cites W2092305624 @default.
- W2000736294 cites W2136350449 @default.
- W2000736294 cites W2167139993 @default.
- W2000736294 cites W4210986357 @default.
- W2000736294 cites W4234059508 @default.
- W2000736294 cites W4240701076 @default.
- W2000736294 doi "https://doi.org/10.1016/0024-3205(93)90596-u" @default.
- W2000736294 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8412502" @default.
- W2000736294 hasPublicationYear "1993" @default.
- W2000736294 type Work @default.
- W2000736294 sameAs 2000736294 @default.
- W2000736294 citedByCount "15" @default.
- W2000736294 countsByYear W20007362942013 @default.
- W2000736294 countsByYear W20007362942019 @default.
- W2000736294 countsByYear W20007362942020 @default.
- W2000736294 crossrefType "journal-article" @default.
- W2000736294 hasAuthorship W2000736294A5013413844 @default.
- W2000736294 hasAuthorship W2000736294A5022470178 @default.
- W2000736294 hasAuthorship W2000736294A5027019614 @default.
- W2000736294 hasAuthorship W2000736294A5052124556 @default.
- W2000736294 hasAuthorship W2000736294A5057311540 @default.
- W2000736294 hasAuthorship W2000736294A5072010155 @default.
- W2000736294 hasAuthorship W2000736294A5072010198 @default.
- W2000736294 hasConcept C112705442 @default.
- W2000736294 hasConcept C126322002 @default.
- W2000736294 hasConcept C150903083 @default.
- W2000736294 hasConcept C170493617 @default.
- W2000736294 hasConcept C185592680 @default.
- W2000736294 hasConcept C207001950 @default.
- W2000736294 hasConcept C2778182776 @default.
- W2000736294 hasConcept C2778938600 @default.
- W2000736294 hasConcept C29730261 @default.
- W2000736294 hasConcept C71924100 @default.
- W2000736294 hasConcept C86803240 @default.
- W2000736294 hasConcept C98274493 @default.
- W2000736294 hasConceptScore W2000736294C112705442 @default.
- W2000736294 hasConceptScore W2000736294C126322002 @default.
- W2000736294 hasConceptScore W2000736294C150903083 @default.
- W2000736294 hasConceptScore W2000736294C170493617 @default.
- W2000736294 hasConceptScore W2000736294C185592680 @default.
- W2000736294 hasConceptScore W2000736294C207001950 @default.
- W2000736294 hasConceptScore W2000736294C2778182776 @default.
- W2000736294 hasConceptScore W2000736294C2778938600 @default.
- W2000736294 hasConceptScore W2000736294C29730261 @default.
- W2000736294 hasConceptScore W2000736294C71924100 @default.
- W2000736294 hasConceptScore W2000736294C86803240 @default.
- W2000736294 hasConceptScore W2000736294C98274493 @default.
- W2000736294 hasIssue "17" @default.
- W2000736294 hasLocation W20007362941 @default.
- W2000736294 hasLocation W20007362942 @default.
- W2000736294 hasOpenAccess W2000736294 @default.
- W2000736294 hasPrimaryLocation W20007362941 @default.
- W2000736294 hasRelatedWork W1491964893 @default.
- W2000736294 hasRelatedWork W1906640546 @default.
- W2000736294 hasRelatedWork W1998587742 @default.
- W2000736294 hasRelatedWork W2004556784 @default.
- W2000736294 hasRelatedWork W2094219250 @default.
- W2000736294 hasRelatedWork W2379311614 @default.
- W2000736294 hasRelatedWork W2388069209 @default.
- W2000736294 hasRelatedWork W2582907174 @default.
- W2000736294 hasRelatedWork W2625601291 @default.
- W2000736294 hasRelatedWork W2753834235 @default.
- W2000736294 hasVolume "53" @default.
- W2000736294 isParatext "false" @default.
- W2000736294 isRetracted "false" @default.
- W2000736294 magId "2000736294" @default.
- W2000736294 workType "article" @default.