FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000737553> ?p ?o ?g. }

• W2000737553 abstract "The Neurospora clock protein FRQ forms a complex with casein kinase 1a (CK1a) and FRH, a DEAD box-containing RNA helicase with a clock-independent essential function in RNA metabolism. In the course of a circadian period, FRQ is progressively hyperphosphorylated and eventually degraded. Timed hyperphosphorylation of FRQ is crucial for timekeeping of the clock. Here we show that the ATPase activity of FRH attenuates the kinetics of CK1a-mediated hyperphosphorylation of FRQ. Hyperphosphorylation of FRQ is strictly dependent on site-specific recruitment of a CK1a molecule that is activated upon binding. The FRH ATPase cycle regulates the access of CK1a to phosphorylation sites in FRQ in cis, suggesting that FRH is an ATP-dependent remodelling factor acting on the protein complex. We show that the affinity of CK1a for FRQ decreases with increasing FRQ phosphorylation, suggesting functional inactivation of FRQ in the negative feedback loop of the circadian clock before and independent of its degradation. CK1a-mediated progressive phosphorylation of FRQ is an essential aspect of the molecular clock in Neurospora. Here, Lauinger et al.demonstrate that the DEAD box helicase FRH acts as an ATP driven remodelling factor of the CK1a/FRQ complex that provides a pacemaker function by attenuating FRQ phosphorylation." @default.
• W2000737553 created "2016-06-24" @default.
• W2000737553 creator A5018609855 @default.
• W2000737553 creator A5023235079 @default.
• W2000737553 creator A5050910293 @default.
• W2000737553 creator A5060668454 @default.
• W2000737553 date "2014-04-07" @default.
• W2000737553 modified "2023-09-26" @default.
• W2000737553 title "The RNA helicase FRH is an ATP-dependent regulator of CK1a in the circadian clock of Neurospora crassa" @default.
• W2000737553 cites W146972387 @default.
• W2000737553 cites W1548090883 @default.
• W2000737553 cites W1588550310 @default.
• W2000737553 cites W1965579368 @default.
• W2000737553 cites W1972249656 @default.
• W2000737553 cites W1976305103 @default.
• W2000737553 cites W1979792723 @default.
• W2000737553 cites W1984709672 @default.
• W2000737553 cites W1991516961 @default.
• W2000737553 cites W2008589209 @default.
• W2000737553 cites W2015391864 @default.
• W2000737553 cites W2019311422 @default.
• W2000737553 cites W2021560988 @default.
• W2000737553 cites W2022127539 @default.
• W2000737553 cites W2027324767 @default.
• W2000737553 cites W2032503508 @default.
• W2000737553 cites W2035571475 @default.
• W2000737553 cites W2036690617 @default.
• W2000737553 cites W2041099435 @default.
• W2000737553 cites W2047049465 @default.
• W2000737553 cites W2060424984 @default.
• W2000737553 cites W2062526657 @default.
• W2000737553 cites W2070856611 @default.
• W2000737553 cites W2078532539 @default.
• W2000737553 cites W2082280257 @default.
• W2000737553 cites W2083977578 @default.
• W2000737553 cites W2087884526 @default.
• W2000737553 cites W2087920243 @default.
• W2000737553 cites W2091190940 @default.
• W2000737553 cites W2096436921 @default.
• W2000737553 cites W2100391534 @default.
• W2000737553 cites W2103724315 @default.
• W2000737553 cites W2109704210 @default.
• W2000737553 cites W2114511731 @default.
• W2000737553 cites W2114921531 @default.
• W2000737553 cites W2118304866 @default.
• W2000737553 cites W2121743466 @default.
• W2000737553 cites W2144695921 @default.
• W2000737553 cites W2146127714 @default.
• W2000737553 cites W2152231771 @default.
• W2000737553 cites W2155697908 @default.
• W2000737553 cites W2165967869 @default.
• W2000737553 cites W2166074837 @default.
• W2000737553 doi "https://doi.org/10.1038/ncomms4598" @default.
• W2000737553 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24710172" @default.
• W2000737553 hasPublicationYear "2014" @default.
• W2000737553 type Work @default.
• W2000737553 sameAs 2000737553 @default.
• W2000737553 citedByCount "40" @default.
• W2000737553 countsByYear W20007375532014 @default.
• W2000737553 countsByYear W20007375532015 @default.
• W2000737553 countsByYear W20007375532016 @default.
• W2000737553 countsByYear W20007375532017 @default.
• W2000737553 countsByYear W20007375532018 @default.
• W2000737553 countsByYear W20007375532019 @default.
• W2000737553 countsByYear W20007375532020 @default.
• W2000737553 countsByYear W20007375532021 @default.
• W2000737553 countsByYear W20007375532022 @default.
• W2000737553 countsByYear W20007375532023 @default.
• W2000737553 crossrefType "journal-article" @default.
• W2000737553 hasAuthorship W2000737553A5018609855 @default.
• W2000737553 hasAuthorship W2000737553A5023235079 @default.
• W2000737553 hasAuthorship W2000737553A5050910293 @default.
• W2000737553 hasAuthorship W2000737553A5060668454 @default.
• W2000737553 hasBestOaLocation W20007375531 @default.
• W2000737553 hasConcept C104317684 @default.
• W2000737553 hasConcept C11960822 @default.
• W2000737553 hasConcept C143065580 @default.
• W2000737553 hasConcept C160110348 @default.
• W2000737553 hasConcept C161223559 @default.
• W2000737553 hasConcept C2776739539 @default.
• W2000737553 hasConcept C2776769606 @default.
• W2000737553 hasConcept C2778198054 @default.
• W2000737553 hasConcept C38606739 @default.
• W2000737553 hasConcept C55493867 @default.
• W2000737553 hasConcept C67705224 @default.
• W2000737553 hasConcept C68592252 @default.
• W2000737553 hasConcept C86803240 @default.
• W2000737553 hasConcept C95444343 @default.
• W2000737553 hasConcept C97029542 @default.
• W2000737553 hasConceptScore W2000737553C104317684 @default.
• W2000737553 hasConceptScore W2000737553C11960822 @default.
• W2000737553 hasConceptScore W2000737553C143065580 @default.
• W2000737553 hasConceptScore W2000737553C160110348 @default.
• W2000737553 hasConceptScore W2000737553C161223559 @default.
• W2000737553 hasConceptScore W2000737553C2776739539 @default.
• W2000737553 hasConceptScore W2000737553C2776769606 @default.
• W2000737553 hasConceptScore W2000737553C2778198054 @default.
• W2000737553 hasConceptScore W2000737553C38606739 @default.
• W2000737553 hasConceptScore W2000737553C55493867 @default.
• W2000737553 hasConceptScore W2000737553C67705224 @default.

• next