Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000739354> ?p ?o ?g. }
- W2000739354 endingPage "1653" @default.
- W2000739354 startingPage "1643" @default.
- W2000739354 abstract "Background: This study aimed to analyze the protective effects of a saponin extract from Radix Pseudostellariae (RP) on retinal laser injury based on a retinal photocoagulation model. Methods: Fifty-eight rabbits were randomly divided into three groups: Group A (saponin extract orally), Group B (physiological saline), and Group C (control). The animals were sacrificed 1 day, 7 days, 14 days, and 30 days after photocoagulation and lesions were evaluated with fundus photography, light microscopy, and electron microscopy. Superoxide dismutase (SOD) and malondialdehyde (MDA) levels were measured, and expression levels of c-fos and Bax genes were also determined. Results: The lesion sizes in Group A were smaller than in Group B. The levels of SOD in Group B were significantly lower than in groups A and C (P<0.001) at all time points. The MDA levels were significantly lower than in groups B and C (P<0.001) at the 1 month point, while the apoptosis rate of Group A was significantly lower than that of Group B at all time points. The expression levels of the c-fos gene in Group B were significantly higher than that in groups A and C, and expression levels of the Bax gene in Group A were significantly lower than that in groups B and C. Conclusion: The saponin extract of RP can inhibit oxidative stress, downregulate the levels of c-fos and Bax gene expression, and inhibit apoptosis in the retina after photocoagulation." @default.
- W2000739354 created "2016-06-24" @default.
- W2000739354 creator A5003799076 @default.
- W2000739354 creator A5026654183 @default.
- W2000739354 creator A5048480814 @default.
- W2000739354 creator A5050699287 @default.
- W2000739354 creator A5066117025 @default.
- W2000739354 creator A5078855963 @default.
- W2000739354 creator A5090474210 @default.
- W2000739354 date "2014-01-01" @default.
- W2000739354 modified "2023-09-23" @default.
- W2000739354 title "Protective Effects of<b><i>Radix Pseudostellariae</i></b>Extract Against Retinal Laser Injury" @default.
- W2000739354 cites W1523213544 @default.
- W2000739354 cites W1577823339 @default.
- W2000739354 cites W1584189653 @default.
- W2000739354 cites W1987315191 @default.
- W2000739354 cites W1987542529 @default.
- W2000739354 cites W1987784248 @default.
- W2000739354 cites W2020820670 @default.
- W2000739354 cites W2039889642 @default.
- W2000739354 cites W2041571364 @default.
- W2000739354 cites W2052324050 @default.
- W2000739354 cites W2053112776 @default.
- W2000739354 cites W2061323000 @default.
- W2000739354 cites W2063988906 @default.
- W2000739354 cites W2075742847 @default.
- W2000739354 cites W2081739252 @default.
- W2000739354 cites W2084141237 @default.
- W2000739354 cites W2086389008 @default.
- W2000739354 cites W2093222242 @default.
- W2000739354 cites W2119926929 @default.
- W2000739354 cites W2128259512 @default.
- W2000739354 cites W2158490450 @default.
- W2000739354 cites W2170967403 @default.
- W2000739354 cites W2211610885 @default.
- W2000739354 cites W2323909850 @default.
- W2000739354 cites W2363884201 @default.
- W2000739354 cites W2380427226 @default.
- W2000739354 cites W2415062407 @default.
- W2000739354 cites W25620139 @default.
- W2000739354 cites W600423657 @default.
- W2000739354 doi "https://doi.org/10.1159/000362947" @default.
- W2000739354 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24902809" @default.
- W2000739354 hasPublicationYear "2014" @default.
- W2000739354 type Work @default.
- W2000739354 sameAs 2000739354 @default.
- W2000739354 citedByCount "7" @default.
- W2000739354 countsByYear W20007393542018 @default.
- W2000739354 countsByYear W20007393542019 @default.
- W2000739354 countsByYear W20007393542022 @default.
- W2000739354 countsByYear W20007393542023 @default.
- W2000739354 crossrefType "journal-article" @default.
- W2000739354 hasAuthorship W2000739354A5003799076 @default.
- W2000739354 hasAuthorship W2000739354A5026654183 @default.
- W2000739354 hasAuthorship W2000739354A5048480814 @default.
- W2000739354 hasAuthorship W2000739354A5050699287 @default.
- W2000739354 hasAuthorship W2000739354A5066117025 @default.
- W2000739354 hasAuthorship W2000739354A5078855963 @default.
- W2000739354 hasAuthorship W2000739354A5090474210 @default.
- W2000739354 hasBestOaLocation W20007393541 @default.
- W2000739354 hasConcept C104317684 @default.
- W2000739354 hasConcept C118487528 @default.
- W2000739354 hasConcept C126322002 @default.
- W2000739354 hasConcept C142724271 @default.
- W2000739354 hasConcept C150194340 @default.
- W2000739354 hasConcept C16685009 @default.
- W2000739354 hasConcept C185592680 @default.
- W2000739354 hasConcept C190283241 @default.
- W2000739354 hasConcept C204787440 @default.
- W2000739354 hasConcept C2775838275 @default.
- W2000739354 hasConcept C2776151105 @default.
- W2000739354 hasConcept C2776391266 @default.
- W2000739354 hasConcept C2776474195 @default.
- W2000739354 hasConcept C2777397205 @default.
- W2000739354 hasConcept C2777785397 @default.
- W2000739354 hasConcept C2778401633 @default.
- W2000739354 hasConcept C2778564307 @default.
- W2000739354 hasConcept C2779091547 @default.
- W2000739354 hasConcept C2780248432 @default.
- W2000739354 hasConcept C2780678043 @default.
- W2000739354 hasConcept C2780827179 @default.
- W2000739354 hasConcept C55493867 @default.
- W2000739354 hasConcept C59822182 @default.
- W2000739354 hasConcept C71924100 @default.
- W2000739354 hasConcept C86803240 @default.
- W2000739354 hasConceptScore W2000739354C104317684 @default.
- W2000739354 hasConceptScore W2000739354C118487528 @default.
- W2000739354 hasConceptScore W2000739354C126322002 @default.
- W2000739354 hasConceptScore W2000739354C142724271 @default.
- W2000739354 hasConceptScore W2000739354C150194340 @default.
- W2000739354 hasConceptScore W2000739354C16685009 @default.
- W2000739354 hasConceptScore W2000739354C185592680 @default.
- W2000739354 hasConceptScore W2000739354C190283241 @default.
- W2000739354 hasConceptScore W2000739354C204787440 @default.
- W2000739354 hasConceptScore W2000739354C2775838275 @default.
- W2000739354 hasConceptScore W2000739354C2776151105 @default.
- W2000739354 hasConceptScore W2000739354C2776391266 @default.
- W2000739354 hasConceptScore W2000739354C2776474195 @default.